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- Table of Contents
Facts about Period circadian protein homolog 3.
It is derived from the Latin roots'circa' (about) and'diem' (day) and acts as an important regulator of a wide variety of physiological functions such as metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major elements: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are found in virtually every tissue and organ system.
Human | |
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Gene Name: | PER3 |
Uniprot: | P56645 |
Entrez: | 8863 |
Belongs to: |
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No superfamily |
Cell growth-inhibiting gene 13 protein; Circadian clock protein PERIOD 3; GIG13; growth-inhibiting protein 13; hPER3; period (Drosophila) homolog 3; period 3; period circadian protein 3; period circadian protein homolog 3; period homolog 3 (Drosophila)
Mass (kDA):
131.888 kDA
Human | |
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Location: | 1p36.23 |
Sequence: | 1; NC_000001.11 (7784285..7845181) |
Cytoplasm. Nucleus. Mainly cytoplasmic. Translocates to the nucleus through binding PER1, PER2, CRY1 or CRY2, but not TIMELESS.
PMID: 11306557 by Ebisawa T., et al. Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome.
PMID: 12841365 by Archer S.N., et al. A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference.
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