PER3 Antibodies

Period circadian protein homolog 3 (PER3)

Originally called a core component of the circadian clock. The circadian clock, an inner time-keeping system, regulates various physiological processes throughout the generation of roughly 24 hour circadian rhythms in gene expression, which can be translated into rhythms in behavior and metabolism.

It is derived from the Latin roots'circa' (about) and'diem' (day) and acts as an important regulator of a wide variety of physiological functions such as metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major elements: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are found in virtually every tissue and organ system.

Gene Information

Human
Gene Name:	PER3
Uniprot:	P56645
Entrez:	8863

Family

Belongs to:
No superfamily

Alternative Names

Cell growth-inhibiting gene 13 protein; Circadian clock protein PERIOD 3; GIG13; growth-inhibiting protein 13; hPER3; period (Drosophila) homolog 3; period 3; period circadian protein 3; period circadian protein homolog 3; period homolog 3 (Drosophila)

Molecular Weight

Mass (kDA):
131.888 kDA

Genomic Context

Human
Location:	1p36.23
Sequence:	1; NC_000001.11 (7784285..7845181)

Subcellular Localizations

Cytoplasm. Nucleus. Mainly cytoplasmic. Translocates to the nucleus through binding PER1, PER2, CRY1 or CRY2, but not TIMELESS.

Diseases

• Malignant Neoplasms
• Variable Number Tandem Repeat
• Sleep Disorders
• Neoplasms
• Sleep Disorders, Circadian Rhythm
• Depressive Disorder
• Bipolar Disorder
• Delayed Sleep Phase Syndrome
• Mood Disorders
• Diabetes Mellitus
• Obesity
• Malignant Neoplasm Of Breast

• Cell Transformation, Neoplastic
• Schizophrenia
• Inflammation
• Nervousness
• Mental Disorders
• Diabetes Mellitus, Non-insulin-dependent

Interacting Proteins

• CHEK2

Pathways

• Circadian Rhythm
• Secretion
• Localization
• Cell Proliferation
• Cell Cycle
• Methylation
• Bioluminescence
• Pathogenesis
• Cognition
• Aging
• Translation
• Nuclear Import
• Nuclear Export

• Glucose Homeostasis
• Swimming
• Cell Differentiation
• Gene Silencing
• Fertilization
• Hormone Secretion
• Insulin Secretion

PTMs

• Phosphorylation
• Methylation

• Glycosylation
• Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PER3

Boster Bio: Best Uses Of The PER3 Marker

If you're not familiar with Steven Boster, read this article to learn more about this company and his high-affinity primary antibodies. The PER3 Marker is a protein that's found in the human bloodstream. Using it as an antibody in a research study can help you detect the presence of the protein in the blood. PER3 is also a key component of human tumor markers, including melanoma.

PER3 Marker

The PER3 gene is a widely used transcription factor that is expressed in the brain and spinal cord. The PER3 protein is regulated by the hormones oxytocin and norepinephrine. Boster's primary antibodies for the PER3 marker are highly specific and highly cited. Boster's antibodies have been validated for use in Western blotting, immunohistochemistry, and ELISA.

High-affinity primary antibodies

PER3 is a protein found in the ECM, whose presence in the body promotes cell migration. Primary antibodies that target Gal-1 have a high affinity for ECM proteins, including osteopontin, thrombospondin, and vitronectin. They also recognize glycosamine glycans such as chondroitin sulfate and heparan sulfate. This combination of proteins may produce an adhesion effect.

PER3

The PER3 gene is one of the core mammalian clock genes, but the most exciting thing about this gene is its variable number of tandem repeats (VNTRs) in the 18th exon. While this VNTR is strongly associated with circadian rhythm phenotypes in humans, it has not been studied in other mammals. In this study, we sought to determine if PER3 VNTRs are present in a large panel of mammals.