Synaptojanin-1 Antibodies

AND SYNJ1 ELISA kits, Synaptojanin-1 Proteins

Many biological assays use antibodies to detect Synaptojanin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Synaptojanin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Synaptojanin-1 antibodies...

We validate the specificity of these antibodies to Synaptojanin-1 by testing them on tissues known to express SYNJ1 positively and negatively. Browse below to find the SYNJ1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SYNJ1 Infographic by Boster Bio

All SYNJ1 Products

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Synaptojanin (SYNJ1) (NM_001160302) Human Recombinant Protein

$1062
Cat # PROTO43426
20 µg

Synaptojanin (SYNJ1) (NM_203446) Human Over-expression Lysate

Human

$960
Cat # LS008867
100 µg

SYNJ1 Overview

Facts about Synaptojanin-1.

SYNJ1 3D structure. Source: alphafold

Synaptojanin-1 (SYNJ1)

Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4,5)-bisphosphate and phosphatidylinositol (3,4,5)-trisphosphate (PubMed:27435091). Has a role in clathrin-mediated endocytosis (By similarity).

Hydrolyzes PIP2 bound to actin regulatory proteins causing the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity). .

Gene Information

Human
Gene Name:	SYNJ1
Uniprot:	O43426
Entrez:	8867

Family

Belongs to:

synaptojanin family

Alternative Names

EC 3.1.3; EC 3.1.3.36; KIAA0910; polyphosphoinositide phosphatase, 10synaptojanin-1; Synaptic inositol-14,5-trisphosphate 5-phosphatase 1; synaptojanin 1

Molecular Weight

Mass (kDA):
173.103 kDA

Genomic Context


Human

Location:	21q22.11
Sequence:	21; NC_000021.9 (32628759..32731247, complement)

Tissue Specificity

Concentrated at clathrin-coated endocytic intermediates in nerve terminals. Isoform 1 is more enriched than isoform 2 in developing brain as well as non-neuronal cells. Isoform 2 is very abundant in nerve terminals.

Subcellular Localizations

Cytoplasm, perinuclear region.

Diseases

Down Syndrome
Bipolar Disorder
Alzheimer's Disease
Borderline Personality Disorder
Impaired Cognition
Malnutrition
Personality Disorders
Trinucleotide Repeat Expansion
Ataxia
Enterovirus Infections
Endoplasmic Reticulum Stress

Autonomic Nervous System Disorders
Maternal Exposure
Paroxysmal Nocturnal Dyspnea
Nervousness
Steroid Sulfatase Deficiency Disease
Dysequilibrium Syndrome

Pathways

Endocytosis
Clathrin-mediated Endocytosis
Synaptic Vesicle Endocytosis
Synaptic Transmission
Pathogenesis
Glycosylation
Glomerular Filtration
Protein Glycosylation
Translation

Synaptic Vesicle Internalization
Membrane Fission
Cognition
Rna Interference

PTMs

Glycosylation

Research Areas

Cellular Markers
Neuronal Cell Markers
Neuroscience
Neurotransmission

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SYNJ1

References

PMID: 9428629 by Haffner C., et al. Synaptojanin 1: localization on coated endocytic intermediates in nerve terminals and interaction of its 170 kDa isoform with Eps15.

PMID: 10542231 by Cestra G., et al. The SH3 domains of endophilin and amphiphysin bind to the proline- rich region of synaptojanin 1 at distinct sites that display an unconventional binding specificity.