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- Table of Contents
Facts about Period circadian protein homolog 2.
It's derived from the Latin roots'circa' (about) and'diem' (day) and acts as an important regulator of a wide array of physiological functions such as metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major elements: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, along with the peripheral clocks which are found in nearly every tissue and organ system.
Human | |
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Gene Name: | PER2 |
Uniprot: | O15055 |
Entrez: | 8864 |
Belongs to: |
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No superfamily |
Circadian clock protein PERIOD 2; FASPS; hPER2; KIAA0347period 2; period (Drosophila) homolog 2; period circadian protein 2; period circadian protein homolog 2; period homolog 2 (Drosophila)
Mass (kDA):
136.579 kDA
Human | |
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Location: | 2q37.3 |
Sequence: | 2; NC_000002.12 (238244038..238290102, complement) |
Widely expressed. Found in heart, brain, placenta, lung, liver, skeleatal muscle, kidney and pancreas. High levels in skeletal muscle and pancreas. Low levels in lung. Isoform 2 is expressed in keratinocytes (at protein level).
[Isoform 1]: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Translocate to the nucleus after phosphorylation by CSNK1D or CSNK1E. Also translocated to the nucleus by CRY1 or CRY2. PML regulates its nuclear localization.; [Isoform 2]: Nucleus, nucleolus.
PMID: 11165242 by Camacho F., et al. Human casein kinase Idelta phosphorylation of human circadian clock proteins period 1 and 2.
PMID: 9427249 by Shearman L.P., et al. Two period homologs: circadian expression and photic regulation in the suprachiasmatic nuclei.