PER2 Antibodies

Period circadian protein homolog 2 (PER2)

Transcriptional repressor which forms a core component of the circadian clock. The circadian clock, an internal time- keeping system, regulates various physiological processes throughout the creation of approximately 24 hour circadian rhythms in gene expression, which are translated to rhythms in behavior and metabolism.

It's derived from the Latin roots'circa' (about) and'diem' (day) and acts as an important regulator of a wide array of physiological functions such as metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major elements: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, along with the peripheral clocks which are found in nearly every tissue and organ system.

Gene Information

Human
Gene Name:	PER2
Uniprot:	O15055
Entrez:	8864

Family

Belongs to:
No superfamily

Alternative Names

Circadian clock protein PERIOD 2; FASPS; hPER2; KIAA0347period 2; period (Drosophila) homolog 2; period circadian protein 2; period circadian protein homolog 2; period homolog 2 (Drosophila)

Molecular Weight

Mass (kDA):
136.579 kDA

Genomic Context

Human
Location:	2q37.3
Sequence:	2; NC_000002.12 (238244038..238290102, complement)

Tissue Specificity

Widely expressed. Found in heart, brain, placenta, lung, liver, skeleatal muscle, kidney and pancreas. High levels in skeletal muscle and pancreas. Low levels in lung. Isoform 2 is expressed in keratinocytes (at protein level).

Subcellular Localizations

[Isoform 1]: Nucleus. Cytoplasm. Cytoplasm, perinuclear region. Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Translocate to the nucleus after phosphorylation by CSNK1D or CSNK1E. Also translocated to the nucleus by CRY1 or CRY2. PML regulates its nuclear localization.; [Isoform 2]: Nucleus, nucleolus.

Diseases

• Malignant Neoplasms
• Neoplasms
• Pituitary Diseases
• Obesity
• Diabetes Mellitus
• Sleep Disorders, Circadian Rhythm
• Sleep Disorders
• Nervousness
• Depressive Disorder
• Mood Disorders
• Malignant Neoplasm Of Breast
• Sleep-wake Schedule Disorder, Advanced Phase Type

• Jet Lag Syndrome
• Cell Transformation, Neoplastic
• Carcinoma
• Mammary Neoplasms
• Diabetes Mellitus, Non-insulin-dependent
• Cardiovascular Diseases

Interacting Proteins

• CSNK1D
• CSNK1E

Pathways

• Circadian Rhythm
• Bioluminescence
• Cell Cycle
• Secretion
• Localization
• Cell Proliferation
• Aging
• Circadian Behavior
• Pathogenesis
• Cell Growth
• Methylation
• Cell Division
• Translation

• Cell Death
• Transport
• Energy Homeostasis
• Rna Interference
• Glucose Homeostasis
• Sensitization
• Protein Phosphorylation

PTMs

• Phosphorylation
• Methylation
• Deacetylation
• Acetylation

• Ubiquitination
• Reduction
• Oxidation
• Dephosphorylation

• Demethylation

Research Areas

• Cancer
• Chromatin Research
• Circadian Rhythm
• Endothelial Cell Markers
• Hypoxia

• Lipid and Metabolism
• Neuroscience
• Signal Transduction
• Transcription Factors and Regulators
• Vision

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PER2

The Best Uses Of The PER2 Marker

The PER2 Marker is an enzyme in the human body that plays a major role in tumor suppression by regulating DNA damage-responsive pathways. In this article, we discuss how the PER2 Marker works in the body and how it can help your research. We'll also cover optimization tips and troubleshooting. By following these guidelines, you can optimize your experiments and improve your results. In every experiment, there is some kind of trouble. Troubleshooting guides are essential for identifying troubleshooting problems and determining how to fix them.

PER2 functions in tumor suppression by regulating DNA damage-responsive pathways

The expression of PER2 in mammary cells is correlated with expression of PIK3CA, P53, and pTEN. However, PER2 expression is positively correlated with PTEN, which may indicate that PER2 interacts with this pathway. Further studies are needed to confirm these results. This article presents an overview of the known biological functions of PER2.

The function of Per2 in cancer is still unclear. While it is known to suppress the growth of tumors by regulating DNA damage-responsive pathways, PER2 is also implicated in the development of metastatic disease. PER2 expression in tumor tissue has been found to decrease the rate of ovarian cancer growth and metastasis. Overexpression of Per2 in tumors may also inhibit the growth of metastases and inhibit autophagy. Furthermore, the gene may inhibit the PI3K/PKB signaling pathway and restrict the angiogenesis of tumors.

PER2 expression is closely related to the development of cancer and its progression. In several cancers, decreased PER2 expression was associated with decreased cell apoptosis. This suggests that downregulation of PER2 may regulate the expression of caspase-8. This may be a cause of the increased cell death of OSCC. Further research is required to understand the mechanism of how PER2 functions in cancer suppression.

Furthermore, loss of PER2 expression is associated with the development of OSCC. Moreover, PER2 may serve as a prognostic biomarker in this disease. In addition, abnormal PER2 expression in OSCC may result in altered expression of other important tumor-related genes. In the present study, mRNA and protein expression levels of PER2, PIK3CA, P53, and caspase-8 were detected in OSCC tissues through western blot and immunohistochemistry.

RNAi screening reveals that the expression of PER2 is associated with carcinogenesis. This mechanism is related to the initiation of cancer and may influence other clock genes. In addition, RNAi technology has been used to silence PER2 expression in human OSCC cells. Knockdown of PER2 decreased cancer cell proliferation, migration, invasion, and G1/G0 phase, as well as the number of cells in the SCC15-induced G1/S cell cycle.

Boster Bio's PER2 Marker

Boster Bio's PER2 Markers are antibodies that recognize PER2 in a wide range of samples. The antibodies may be polyclonal or monoclonal, and they react with PER2 in many different types of animal samples. Boster Bio developed their antibodies for mouse and rabbit. The circadian clock is a biological clock that regulates many physiological processes, including gene expression. Circadian rhythms in gene expression translate into changes in metabolism and behavior.

Optimization

Biological assays often utilize antibodies to detect PER2. These antibodies can be monoclonal or polyclonal and react with PER2 protein from a variety of animal samples. Boster Bio uses mouse and rabbit as the animals for the development of their PER2 antibody. The PER2 marker is regulated by the circadian clock, which governs several physiological processes. Circadian rhythms translate into regulated gene expression, behavior, and metabolism.