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PELI1 Antibodies
AND PELI1 ELISA kits, PELI1 Proteins
Many biological assays use antibodies to detect PELI1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PELI1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PELI1 antibodies...
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PELI1 Infographic by Boster Bio
All PELI1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$523
Cat # M05921
100 µl
Cat # M05921
100 µl
PELI1 Overview
Facts about E3 ubiquitin-protein ligase pellino homolog 1.
E3 ubiquitin-protein ligase pellino homolog 1 (PELI1)
E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. Involved in the TLR and IL-1 signaling pathways through interaction with the complex containing IRAK kinases and TRAF6.
Mediates 'Lys-63'-linked polyubiquitination of IRAK1 allowing subsequent NF-kappa-B activation (PubMed:12496252, PubMed:17675297). Mediates 'Lys-48'- linked polyubiquitination of RIPK3 leading to its subsequent proteasome-dependent degradation; preferentially recognizes and mediates the degradation of the 'Thr-182' phosphorylated form of RIPK3 (PubMed:29883609).
Gene Information
| Human | |
|---|---|
| Gene Name: | PELI1 |
| Uniprot: | Q96FA3 |
| Entrez: | 57162 |
Family
| Belongs to: |
|---|
| pellino family |
Alternative Names
DKFZp686C18116; MGC50990; pellino (Drosophila) homolog 1; pellino homolog 1 (Drosophila); pellino-1; Pellino-related intracellular-signaling molecule; PRISM; protein pellino homolog 1
Molecular Weight
Mass (kDA):
46.286 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p14 |
| Sequence: | 2; NC_000002.12 (64092652..64144421, complement) |
Tissue Specificity
Expressed at high levels in normal skin but decreased in keratinocytes from toxic epidermal necrolysis (TEN) patients (at protein level).
Diseases
- Inflammation
- Autoimmunity
- Mucocutaneous Lymph Node Syndrome
- Innate Immune Response
- Infective Disorder
- Aneurysm
- Picornaviridae Infections
- Coronary Aneurysm
- Retinitis Pigmentosa
- Virus Diseases
Interacting Proteins
- IRAK1
- IRAK4
- TRIP13
- VAC14
Pathways
- Cell Activation
- T Cell Activation
- Innate Immune Response
- Immune Response
- Rna Interference
- Regeneration
- Cell Proliferation
- Cytokine Production
- Cell Cycle
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PELI1
bosterbio.com/bosterbio-gene-info-cards/PELI1
References
PMID: 11132151 by Rich T., et al. Pellino-related sequences from Caenorhabditis elegans and Homo sapiens.
PMID: 11306823 by Resch K., et al. Assignment of homologous genes, Peli1/PELI1 and Peli2/PELI2, for the Pelle adaptor protein Pellino to mouse chromosomes 11 and 14 and human chromosomes 2p13.3 and 14q21, respectively, by physical and radiation hybrid mapping.