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PEG10 Antibodies
AND PEG10 ELISA kits, PEG10 Proteins
Many biological assays use antibodies to detect PEG10, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PEG10 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PEG10 antibodies...
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PEG10 Overview
Facts about Retrotransposon-derived protein PEG10.
Retrotransposon-derived protein PEG10 (PEG10)
Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation.
Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1.
Gene Information
| Human | |
|---|---|
| Gene Name: | PEG10 |
| Uniprot: | Q86TG7 |
| Entrez: | 23089 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
EDR; embryonal carcinoma differentiation regulated; Embryonal carcinoma differentiation-regulated protein; HB-1; KIAA1051EDR; Mammalian retrotransposon-derived protein 2; Mar2; Mart2; MEF3 Like 1; MEF3L; MEF3L1; Myelin expression factor 3-like protein 1; paternally expressed 10; Paternally expressed gene 10 protein; PEG10; retrotransposon gag domain containing 3; Retrotransposon gag domain-containing protein 3; Retrotransposon-derived gag-like polyprotein; retrotransposon-derived protein PEG10; RGAG3; RGAG3MEF3-like protein 1; RTL2; SIRH1; Ty3/Gypsy-like protein
Molecular Weight
Mass (kDA):
80.173 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q21.3 |
| Sequence: | 7; NC_000007.14 (94656325..94669695) |
Tissue Specificity
Expressed in the cytotrophoblast layer but not in the overlying syncytiotrophoblast of the placenta. Expressed in prostate and breast carcinomas but not in normal breast and prostate epithelial cells. Expressed in the Hep-G2 cell line (at protein level). Expressed in brain, liver, spleen, kidney, thymus, lung, ovary, testis, reactive lymph node, skeletal muscle, adipose tissue and placenta. Expressed in pancreatic and hepatocellular carcinomas (HCC).
Subcellular Localizations
Nucleus. Cytoplasm. Detected predominantly in the cytoplasm of breast and prostate carcinomas, in hepatocellular carcinoma (HCC) and B-cell chronic lymphocytic leukemia (B-CLL) cells and in the Hep-G2 cell line. Colocalized with ALK1.
Diseases
- Carcinoma
- Liver Carcinoma
- Malignant Neoplasms
- Neoplasms
- Liver Neoplasms
- Benign Mixed Epithelial And Stromal Tumor Of Kidney
- Malignant Paraganglionic Neoplasm
- Leukemia
- Fetal Growth Retardation
- Cell Invasion
- Lymphoid Leukemia
- Neoplasm Metastasis
Interacting Proteins
- CALCOCO2
- LDOC1
- RTL8A
- RTL8B
- RTL8C
- SIAH1
- TOLLIP
Pathways
- Methylation
- Dna Methylation
- Cell Proliferation
- Fertilization
- Translation
- Pathogenesis
- Embryo Development
- Cell Differentiation
- Oogenesis
- Localization
- Demethylation
- Drug Resistance
- Rna Interference
PTMs
- Methylation
- Demethylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PEG10
bosterbio.com/bosterbio-gene-info-cards/PEG10
References
PMID: 11318613 by Ono R., et al. A retrotransposon-derived gene, PEG10, is a novel imprinted gene located on human chromosome 7q21.
PMID: 12620933 by Smallwood A., et al. Temporal regulation of the expression of syncytin (HERV-W), maternally imprinted PEG10, and SGCE in human placenta.