PDE7A Antibodies

AND PDE7A ELISA kits, PDE7A Proteins

Many biological assays use antibodies to detect PDE7A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDE7A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDE7A antibodies...

We validate the specificity of these antibodies to PDE7A by testing them on tissues known to express PDE7A positively and negatively. Browse below to find the PDE7A antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PDE7A Infographic by Boster Bio

All PDE7A Products

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Specificity

Applications

Price

Anti-PDE7A Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A02162
100ul

PDE7A (NM_002603) Human Over-expression Lysate

Human

$960
Cat # LS005150
100 µg

PDE7A Overview

Facts about High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A.

PDE7A 3D structure. Source: alphafold

High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A (PDE7A)

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a function in muscle signal transduction.

Gene Information

Human
Gene Name:	PDE7A
Uniprot:	Q13946
Entrez:	5150

Family

Belongs to:

cyclic nucleotide phosphodiesterase family

Alternative Names

EC 3.1.4; EC 3.1.4.17; HCP1high affinity cAMP-specific 3'-5'-cyclic phosphodiesterase 7A; PDE7; phosphodiesterase 7A; phosphodiesterase isozyme 7; TM22

Molecular Weight

Mass (kDA):
55.505 kDA

Genomic Context


Human

Location:	8q13.1
Sequence:	8; NC_000008.11 (65714334..65842064, complement)

Tissue Specificity

PDE7A1 is found at high levels in skeletal muscle and at low levels in a variety of tissues including brain and heart. It is expressed as well in two T-cell lines. PDE7A2 is found abundantly in skeletal muscle and at low levels in heart.

Subcellular Localizations

[Isoform PDE7A1]: Cytoplasm, cytosol. PDE7A1 (57 kDa) is located mostly to soluble cellular fractions.; [Isoform PDE7A2]: Cytoplasm. PDE7A2 (50 kDa) is located to particulate cellular fractions.

Diseases

Inflammation
Dermatitis
Lung Diseases
Lung Diseases, Obstructive
Psoriasis
Chronic Obstructive Airway Disease
Edema
Asthma
Autoimmune Reaction
Vomiting
Sclerosis
Malignant Neoplasms
Rheumatoid Arthritis

Chronic Inflammation
Hepatitis
Autoimmune Diseases
Arthritis
Osteosarcoma
Chronic Lymphocytic Leukemia
Multiple Sclerosis

Pathways

Cytokine Production
Cell Activation
T Cell Activation
Cell Proliferation
Localization
Pathogenesis
Cellular Response To Dsrna
Gene Silencing
Aging
Hypersensitivity
T Cell Proliferation
Cell Differentiation
Dsrna Fragmentation

Catabolic Process
Induction Of Apoptosis
Camp-mediated Signaling
Insulin Secretion
Response To Dsrna
Penile Erection
Intracellular Signal Transduction

PTMs

Phosphorylation

Cleavage

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDE7A

References

PMID: 8389765 by Michaeli T., et al. Isolation and characterization of a previously undetected human cAMP phosphodiesterase by complementation of cAMP phosphodiesterase- deficient Saccharomyces cerevisiae.

PMID: 9195912 by Han P., et al. Alternative splicing of the high affinity cAMP-specific phosphodiesterase (PDE7A) mRNA in human skeletal muscle and heart.