Myomegalin Antibodies

Myomegalin (PDE4DIP)

Functions as an anchor sequestering components of this cAMP-dependent pathway to Golgi and/or centrosomes (By similarity). .

Gene Information

Human
Gene Name:	PDE4DIP
Uniprot:	Q5VU43
Entrez:	9659

Family

Belongs to:
No superfamily

Alternative Names

Cardiomyopathy-associated protein 2; CMYA2; DKFZp781J054; KIAA0454; KIAA0477; MGC75440; MMGLcardiomyopathy associated 2; myomegalin; phosphodiesterase 4D interacting protein; Phosphodiesterase 4D-interacting protein

Molecular Weight

Mass (kDA):
265.103 kDA

Genomic Context

Human
Location:	1q21.2
Sequence:	1; NC_000001.11 (148808198..149051277)

Tissue Specificity

Highly expressed in adult and fetal heart, in skeletal muscle and, to a lower extent, in brain and placenta.

Subcellular Localizations

Golgi apparatus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome.; [Isoform 13]: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton. Golgi apparatus. Associated with the microtubule network at the growing distal tip of microtubules (PubMed:29162697). Targeting to the Golgi apparatus requires AKAP9 (PubMed:25217626).

Diseases

• Aneurysm
• Brain Ischemia
• Hemangioma
• Angioma, Cavernous
• Carcinoma
• Tumor Angiogenesis
• Malignant Neoplasms
• Neoplasms
• Cerebrovascular Accident
• Senile Cerebral Amyloid Angiopathy
• Eosinophilia
• Esophageal Neoplasms
• Hypertrophic Cardiomyopathy

• Microcephaly
• Cerebral Amyloid Angiopathy
• Malignant Squamous Cell Neoplasm
• Schizophrenia
• Cadasil Syndrome
• Myeloproliferative Disease
• Mental Disorders

Interacting Proteins

• AEN
• Ankrd1
• BYSL
• C1orf109
• CCDC198

• CHCHD3
• COMMD4
• Eno1
• Eno3
• FAM161A

• FAM74A4
• GOLGA8DP
• GOLGA8F
• HAUS1
• IMMT

• KLC3
• LENG1
• LMO4
• MAPRE1
• MIF4GD

• MTUS2
• MYBPC3
• NAA10
• PPP1R18
• Prkar1a

• Prkar2a
• PRPF31
• RTP5
• RYDEN
• SCNM1

• SDCBP
• SH2D4A
• TNNI3
• Tnni3
• ZFYVE21

• ZNF408
• ZNF581
• ZSCAN26

Pathways

• Transport
• Angiogenesis
• Interphase
• Nuclear Import

PTMs

• Phosphorylation

• Cleavage

• Dephosphorylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDE4DIP

Best Uses Of The PDE4DIP Marker

What is the PDE4DIP mark and how can it possibly be used? Boster bio explains PDE4DIP. This is the acronym for phosphodiesterases and is one among the smallest proteins in our bodies. The PDE4DIP marker, a small fluorescent protein that binds with PDE4D or D, is widely used in many research areas, including cell culture and tissue culture.

Genomatix Pathway Systems

Software has been used by researchers to create networks of gene/gene interactions and connect them. There's a problem. These systems aren’t as intuitive or as simple as they could be. Genomatix Pathway System was created to assist scientists in visualizing complex genetic networks and identifying key players in biological processes. This software can be used to access public and proprietary databases for analysis and discovery. It can be confusing at first.

The Genomatix Pathway System's data sets contain hundreds of thousands of pathways. The Alox5 gene code is involved in inflammatory diseases, pain and thrombosis. It interacts via IL-6 and TNF signalsling pathways. This system may be used to help researchers identify diseases whose genes are associated with certain types. By doing this, they can target particular genes to find out their role within a given condition.

Researchers can identify genes that are associated to pain and other conditions using the Genomatix Pathway System. TRPV1 comes from the chemokine gene cluster and is expressed by inflammatory cells. It is involved in inflammatory pain, vascular disease, and autoimmune disorders. Genomatix data sets contain relationships between TNF and Tgf. TNF can either regulate or inhibit many pathways, including MAPK1, Akt-1 and PKC.

PDE4DIP Marker

A genetic mutation of PDE4DIP, which is a gene that anchors 4D phosphodiesterase in the Golgi/centrosome of the cell, may affect a person's risk of developing cancer. PDE4DIP alteration is found in 0.93% all cancers. The most common types are breast invasive, ductal carcinoma and mixed breast and ductal cancer.

History of Steven Boster

Steven Boster's background is likely to interest you if you are a fan the U.S. Army. Steve Boster, a former Special Forces vet, was a decorated veteran. He was a successful retailer sales manager and a Concordia Hall member. His brother Jack Boster, his sister Tammy Blanton, and niece and nephew are also survivors.

Steve was a man who valued his family above everything else. He sang in the lowest register in front of his family. He loved auto racing and sports in general. His passion for auto racing was evident by the fact that he was always the first to call if his car had broken down at 2 am. He even showed up at appointments in below freezing temperatures! His generous nature extended to his friends and family. He treated them as if they were his family.