PDE4B Antibodies

AND PDE4B ELISA kits, PDE4B Proteins

Many biological assays use antibodies to detect PDE4B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDE4B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDE4B antibodies...

We validate the specificity of these antibodies to PDE4B by testing them on tissues known to express PDE4B positively and negatively. Browse below to find the PDE4B antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PDE4B Infographic by Boster Bio

All PDE4B Products

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Product

Figures

Specificity

Applications

Price

Anti-Phospho-PDE4B/C/D (S133/119/190) Antibody

Human, Mouse, Rat

ELISA, IHC, WB

$380
Cat # A02228S133
100ul

Anti-PDE4B/C/D Antibody

Human, Mouse, Rat

ELISA, IHC, WB

$380
Cat # A02228
100ul

PDE4 (PDE4B) (NM_001037341) Human Recombinant Protein

$1249
Cat # PROTQ07343
20 µg

Anti-PDE4 (PDE4B) Mouse Monoclonal Antibody [Clone ID: OTI1D12]

+10

Human, Mouse, Rat

Flow Cytometry, IF, IHC, WB

$523
Cat # M02228
100 µl

Anti-PDE4B Rabbit Monoclonal Antibody

Human, Mouse

Flow Cytometry, WB

$370
Cat # M02228-1
100 μl/vial

PDE4 (PDE4B) (NM_002600) Human Over-expression Lysate

Human

$960
Cat # LS005142
100 µg

PDE4B Overview

Facts about cAMP-specific 3',5'-cyclic phosphodiesterase 4B.

PDE4B 3D structure. Source: alphafold

cAMP-specific 3',5'-cyclic phosphodiesterase 4B (PDE4B)

Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents which range from antidepressants to antiasthmatic and anti inflammatory agents.

Gene Information

Human
Gene Name:	PDE4B
Uniprot:	Q07343
Entrez:	5142

Family

Belongs to:

cyclic nucleotide phosphodiesterase family

Alternative Names

cAMP-specific (phosphodiesterase E4 dunce homolog; cAMP-specific 3'-5'-cyclic phosphodiesterase 4B; cAMP-specific phosphodiesterase-4 B isoform; DKFZp686F2182; Drosophila); dunce-like phosphodiesterase E4; EC 3.1.4; EC 3.1.4.17; MGC126529; PDE32; PDEIVB; phosphodiesterase 4B, cAMP-specific (dunce (Drosophila)-homologphosphodiesterase E4); phosphodiesterase 4B, cAMP-specific (dunce; phosphodiesterase 4B, cAMP-specific; phosphodiesterase E4 dunce homolog

Molecular Weight

Mass (kDA):
83.343 kDA

Genomic Context


Human

Location:	1p31.3
Sequence:	1; NC_000001.11 (65792510..66374579)

Tissue Specificity

Expressed in brain, heart, lung and skeletal muscle.

Diseases

Schizophrenia
Inflammation
Depressive Disorder
Mental Disorders
Malignant Neoplasms
Asthma
Bipolar Disorder
Vomiting
Neoplasms
Chronic Obstructive Airway Disease
Tissue Adhesions
Lung Diseases
Lymphoma

Lung Diseases, Obstructive
B-cell Lymphomas
Major Depressive Disorder
Diffuse Large B-cell Lymphoma
Leukemia
Nausea
Autoimmune Reaction

Pathways

Pathogenesis
Secretion
Localization
Cell Proliferation
Immune Response
Chemotaxis
Cell Cycle
Cytokine Production
Cell Adhesion
Cell Activation
Cell Migration
Regeneration
Inflammatory Response

Reverse Transcription
Cell Death
Cellular Localization
Brain Development
Mrna Splicing
T Cell Proliferation
Prepulse Inhibition

PTMs

Phosphorylation
Cleavage

Methylation
Acetylation

Dephosphorylation

Research Areas

Cancer
Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDE4B

References

PMID: 8392015 by Obernolte R., et al. The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE IV) reveals a multigene family.

PMID: 8413254 by Bolger G., et al. A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.