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PDE4A Antibodies
AND PDE4A ELISA kits, PDE4A Proteins
Many biological assays use antibodies to detect PDE4A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDE4A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDE4A antibodies...
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PDE4A Infographic by Boster Bio
All PDE4A Products
Product
Figures
Specificity
Applications
Price
Human, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M02714-1
100 µl
Cat # M02714-1
100 µl
Human, Rat
Flow Cytometry, IF, IHC, WB
$523
Cat # M02714
100 µl
Cat # M02714
100 µl
PDE4A Overview
Facts about cAMP-specific 3',5'-cyclic phosphodiesterase 4A.
cAMP-specific 3',5'-cyclic phosphodiesterase 4A (PDE4A)
Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. .
Gene Information
| Human | |
|---|---|
| Gene Name: | PDE4A |
| Uniprot: | P27815 |
| Entrez: | 5141 |
Family
| Belongs to: |
|---|
| cyclic nucleotide phosphodiesterase family |
Alternative Names
cAMP-specific 3'-5'-cyclic phosphodiesterase 4A; DPDE2; DPDE2cAMP-specific phosphodiesterase; EC 3.1.4; EC 3.1.4.17; PDE4; PDE46; PDE4A; Phosphodiesterase 4A; phosphodiesterase 4A, cAMP-specific (dunce (Drosophila)-homologphosphodiesterase E2); phosphodiesterase 4A, cAMP-specific (dunce; phosphodiesterase 4A, cAMP-specific; phosphodiesterase E2 dunce homolog, Drosophila; phosphodiesterase isozyme 4
Molecular Weight
Mass (kDA):
98.143 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 19p13.2 |
| Sequence: | 19; NC_000019.10 (10416773..10469631) |
Tissue Specificity
Isoform 1 is widely expressed. Isoform 2 is abundant in liver, stomach, testis, thyroid and adrenal glands. It is also found in placenta, kidney, pancreas, ovary, uterus, skin, monocytes, mast cells, macrophages, as well as in bronchial smooth muscle. Isoform 6 is expressed at high levels in the heart and small intestine. It is also found in the brain, kidney, spleen, colon, salivary gland, ovary and peripheral blood lymphocytes. Isoform 7 is expressed predominantly in skeletal muscle and brain and at lower levels in the testis. Isoform 7 is expressed in the brain. Found in specific neuronal subpopulations in cortex, spinal cord and cerebellum (at protein level).
Subcellular Localizations
[Isoform 1]: Cytoplasm, perinuclear region.; [Isoform 2]: Cytoplasm, perinuclear region. Cell projection, ruffle membrane.; [Isoform 4]: Membrane; Peripheral membrane protein. Isoform 4 has propensity for association with membranes.; [Isoform 6]: Cytoplasm, perinuclear region.; [Isoform 7]: Cytoplasm. Membrane. Predominantly cytoplasmic.
Diseases
- Inflammation
- Asthma
- Lung Diseases
- Depressive Disorder
- Chronic Obstructive Airway Disease
- Schizophrenia
- Lung Diseases, Obstructive
- Vomiting
- Neoplasms
- Hypertensive Disease
- Inflammatory Response
- Erectile Dysfunction
- Autistic Disorder
Pathways
- Localization
- Cell Proliferation
- Pathogenesis
- Mrna Splicing
- Spermatogenesis
- Cognition
- Inflammatory Response
- Reverse Transcription
- T Cell Proliferation
- Cell Death
- Secretion
- Cell Activation
- Regeneration
PTMs
- Phosphorylation
- Cleavage
Research Areas
- Apoptosis
- Signal Transduction
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDE4A
bosterbio.com/bosterbio-gene-info-cards/PDE4A
References
PMID: 8413254 by Bolger G., et al. A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs.
PMID: 7888306 by Sullivan M., et al. Molecular cloning and expression, in both COS-1 cells and S. cerevisiae, of a human cytosolic type-IVA, cyclic AMP specific phosphodiesterase (hPDE-IVA-h6.1).