PDE3B Antibodies

AND PDE3B ELISA kits, PDE3B Proteins

Many biological assays use antibodies to detect PDE3B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PDE3B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PDE3B antibodies...

We validate the specificity of these antibodies to PDE3B by testing them on tissues known to express PDE3B positively and negatively. Browse below to find the PDE3B antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PDE3B Infographic by Boster Bio

All PDE3B Products

Product

Figures

Specificity

Applications

Price

Anti-PDE3B Antibody

Human, Mouse

$405
Cat # A03323
100ul

PDE3B (NM_000922) Human Recombinant Protein

$1249
Cat # PROTQ13370
20 µg

Anti-PDE3B Mouse Monoclonal Antibody [Clone ID: OTI3F5]

Human

$523
Cat # M03323
100 µl

PDE3B Overview

Facts about cGMP-inhibited 3',5'-cyclic phosphodiesterase B.

PDE3B 3D structure. Source: alphafold

cGMP-inhibited 3',5'-cyclic phosphodiesterase B (PDE3B)

Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. May play a role in fat metabolism.

Regulates cAMP binding of RAPGEF3. Through simultaneous binding to RAPGEF3 and PIK3R6 assembles a signaling complex in which the PI3K gamma complex is activated by RAPGEF3 and which is involved in angiogenesis.

Gene Information

Human
Gene Name:	PDE3B
Uniprot:	Q13370
Entrez:	5140

Family

Belongs to:

cyclic nucleotide phosphodiesterase family

Alternative Names

CGIP1; CGI-PDE B; cGIPDE1; cGMP-inhibited 3'-5'-cyclic phosphodiesterase B; Cyclic GMP-inhibited phosphodiesterase B; cyclic nucleotide phosphodiesterase; EC 3.1.4; EC 3.1.4.17; HcGIP1; phosphodiesterase 3B, cGMP-inhibited

Molecular Weight

Mass (kDA):
124.333 kDA

Genomic Context


Human

Location:	11p15.2
Sequence:	11; NC_000011.10 (14643691..14874139)

Tissue Specificity

Abundant in adipose tissues.

Subcellular Localizations

Membrane; Multi-pass membrane protein.

Diseases

Obesity
Insulin Resistance
Diabetes Mellitus
Diabetes Mellitus, Non-insulin-dependent
Malignant Neoplasms
Heart Failure
Insulinoma
Lymphoid Leukemia
Chronic Lymphocytic Leukemia
Leukemia
Observation Of Neuromuscular Block
Chronic Obstructive Airway Disease

Tissue Adhesions
Insulin Sensitivity
Hypertensive Disease
Lung Diseases
Lung Diseases, Obstructive
Headache
Diabetes Mellitus, Experimental

Interacting Proteins

PIK3CG
PIK3R6
RAPGEF3

Pathways

Secretion
Insulin Secretion
Energy Homeostasis
Translation
Localization
Cell Cycle
Exocytosis
Regulation Of Energy Homeostasis
Induction Of Apoptosis
Regulation Of Insulin Secretion
Pathogenesis
Response To Camp
Gluconeogenesis

Cell Cycle Arrest
Platelet Aggregation
Vasodilation
Oocyte Maturation
Transport
Cell Adhesion
Adiponectin Secretion

PTMs

Phosphorylation
Dephosphorylation
Nitrosylation

Reduction
Methylation
Acylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PDE3B

References

PMID: 8884271 by Miki T., et al. Characterization of the cDNA and gene encoding human PDE3B, the cGIP1 isoform of the human cyclic GMP-inhibited cyclic nucleotide phosphodiesterase family.

PMID: 8706823 by Murata T., et al. Differential expression of cGMP-inhibited cyclic nucleotide phosphodiesterases in human hepatoma cell lines.