PCSK6 Antibodies

AND PCSK6 ELISA kits, PCSK6 Proteins

Many biological assays use antibodies to detect PCSK6, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PCSK6 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PCSK6 antibodies...

We validate the specificity of these antibodies to PCSK6 by testing them on tissues known to express PCSK6 positively and negatively. Browse below to find the PCSK6 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PCSK6 Infographic by Boster Bio

All PCSK6 Products

Product

Figures

Specificity

Applications

Price

Anti-PACE4/PCSK6 Antibody Picoband™

6 Q&As

Human, Rat

$370
Cat # PB9769
100 μg/vial

PACE4 (PCSK6) (NM_138322) Human Over-expression Lysate

Human

$960
Cat # LS005046
100 µg

PCSK6 Overview

Facts about Proprotein convertase subtilisin/kexin type 6.

PCSK6 3D structure. Source: alphafold

Proprotein convertase subtilisin/kexin type 6 (PCSK6)

Serine endoprotease that processes various proproteins by cleavage at paired basic amino acids, recognizing the RXXX[KR]R consensus motif. Likely functions in the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues.

Gene Information

Human
Gene Name:	PCSK6
Uniprot:	P29122
Entrez:	5046

Family

Belongs to:

peptidase S8 family

Alternative Names

EC 3.4.21; EC 3.4.21.61; EC 3.4.21.75; PACE4; PACE4/PCSK6; PACE4EC 3.4.21.-; Paired basic amino acid cleaving enzyme 4; paired basic amino acid cleaving system 4; PCSK6; Proprotein Convertase 6; proprotein convertase subtilisin/kexin type 6; SPC4; SPC4subtilisin-like protease; Subtilisin/kexin-like protease PACE4; Subtilisin-like proprotein convertase 4

Molecular Weight

Mass (kDA):
106.42 kDA

Genomic Context


Human

Location:	15q26.3
Sequence:	15; NC_000015.10 (101303928..101489984, complement)

Tissue Specificity

Each PACE4 isoform exhibits a unique restricted distribution. Isoform PACE4A-I is expressed in heart, brain, placenta, lung, skeletal muscle, kidney, pancreas, but at comparatively higher levels in the liver. Isoform PACE4A-II is at least expressed in placenta. Isoform PACE4B was only found in the embryonic kidney cell line from which it was isolated. Isoform PACE4C and isoform PACE4D are expressed in placenta. Isoform PACE4E-I is expressed in cerebellum, placenta and pituitary. Isoform PACE4E-II is at least present in cerebellum.

Subcellular Localizations

[Isoform PACE4A-I]: Secreted.; [Isoform PACE4A-II]: Secreted.; [Isoform PACE4C]: Endoplasmic reticulum. Not secreted, remains probably in zymogen form in endoplasmic reticulum.; [Isoform PACE4CS]: Endoplasmic reticulum. Not secreted, remains probably in zymogen form in endoplasmic reticulum.; [Isoform PACE4E-I]: Endomembrane system; Peripheral membrane protein. Retained intracellularly probably through a hydrophobic cluster in their C-terminus.; [Isoform PACE4E-II]: Endomembrane system; Peripheral membrane protein. Retained intracellularly probably through a hydrophobic cluster in their C-term