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, No Gclids
Glycodelin Antibodies
AND PAEP ELISA kits, Glycodelin Proteins
Many biological assays use antibodies to detect Glycodelin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Glycodelin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Glycodelin antibodies...
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PAEP Overview
Facts about Glycodelin.
Glycodelin (PAEP)
Glycoprotein that regulates critical steps during fertilization and has immunomonomodulatory effects. Four glycoforms, namely glycodelin-S, -A, -F and -C have been identified in reproductive cells which differ in glycosylation and biological activity.
Glycodelin-A has contraceptive and immunosuppressive activities (PubMed:9918684, PubMed:7531163). Glycodelin-C stimulates binding of spermatozoa to the zona pellucida (PubMed:17192260).
Gene Information
| Human | |
|---|---|
| Gene Name: | PAEP |
| Uniprot: | P09466 |
| Entrez: | 5047 |
Family
| Belongs to: |
|---|
| calycin superfamily |
Alternative Names
alpha uterine protein; GdF; GdS; Glycodelin; glycodelin-A; glycodelin-F; glycodelin-S; MGC138509; MGC142288; PAEP; PEP; Placental protein 14; PP14 protein (placental protein 14); PP14; PP14GDPAEGGdA; pregnancy-associated endometrial a; Pregnancy-associated endometrial alpha-2 globulin; pregnancy-associated endometrial alpha-2-globulin; progestagen-associated endometrial protein (placental protein 14; progestagen-associated endometrial proteinPEG; Progesterone-associated endometrial protein
Molecular Weight
Mass (kDA):
20.624 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 9q34.3 |
| Sequence: | 9; NC_000009.12 (135561627..135566955) |
Tissue Specificity
This protein is, the main protein synthesized and secreted in the endometrium from mid-luteal phase of the menstrual cycle and during the first semester of pregnancy (PubMed:3667877). Glycodelin-A is expressed in amniotic fluid, endometrium/decidua and maternal serum (at protein level) (PubMed:3194393). Glycodelin-F is expressed in follicular fluid, luteinized granulosa cells and the oviduct (at protein level) (PubMed:12672671). Glycodelin-S is expressed in seminal plasma and seminal vesicles (at protein level) (PubMed:9239694). Glycodelin-C is detected in cumulus cells (at protein level), but cumulus cells do not synthesize Glycodelin-C but take up and convert glycodelin- A and -F vis glycan remodeling (PubMed:17192260).
Subcellular Localizations
Secreted.
Diseases
- Endometrial Polyp
- Infertility
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Malignant Paraganglionic Neoplasm
- Flushing
- Hemorrhage
- Female Infertility
- Ovarian Neoplasm
- Adenocarcinoma
- Mammary Neoplasms
Interacting Proteins
- GRAMD2B
Pathways
- Secretion
- Fertilization
- Glycosylation
- Localization
- Cell Proliferation
- Ovulation
- Acrosome Reaction
- Protein Secretion
- Cell Death
- Cell Activation
- T Cell Activation
- Cell Differentiation
- Menstruation
PTMs
- Glycosylation
- Deglycosylation
- Phosphorylation
- Biotinylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PAEP
bosterbio.com/bosterbio-gene-info-cards/PAEP
References
PMID: 3194393 by Julkunen M., et al. Complete amino acid sequence of human placental protein 14: a progesterone-regulated uterine protein homologous to beta- lactoglobulins.
PMID: 2206398 by Vaisse C., et al. Human placental protein 14 gene: sequence and characterization of a short duplication.