ProSAAS Antibodies

AND PCSK1N ELISA kits, ProSAAS Proteins

Many biological assays use antibodies to detect ProSAAS, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ProSAAS in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ProSAAS antibodies...

We validate the specificity of these antibodies to ProSAAS by testing them on tissues known to express PCSK1N positively and negatively. Browse below to find the PCSK1N antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PCSK1N Infographic by Boster Bio

All PCSK1N Products

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Specificity

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Price

Human PCSK1N Recombinant Protein

SDS-PAGE, Denatured

$268
Cat # PROTQ9UHG2
Starting from 10ug

ProSAAS (PCSK1N) (NM_013271) Human Over-expression Lysate

Human

$628
Cat # LS027344
100 µg

PCSK1N Overview

Facts about ProSAAS.

PCSK1N 3D structure. Source: alphafold

ProSAAS (PCSK1N)

May be the control of the neuroendocrine secretory pathway. ProSAAS and Big PEN-LEN, both containing the C-terminal inhibitory domainname, but not the additional processed peptides reduce PCSK1 action in the endoplasmic reticulum and Golgi.

It lowers the action of the 84 kDa form but not the autocatalytically derived 66 kDa form of PCSK1. Subsequent processing of proSAAS may eliminate the inhibition.

Gene Information

Human
Gene Name:	PCSK1N
Uniprot:	Q9UHG2
Entrez:	27344

Family

Belongs to:

No superfamily

Alternative Names

granin-like neuroendocrine peptide; Proprotein convertase 1 inhibitor; proprotein convertase subtilisin/kexin type 1 inhibitorPROSAAS; proSAAS; pro-SAAS; SAAS

Molecular Weight

Mass (kDA):
27.372 kDA

Genomic Context


Human

Location:	Xp11.23
Sequence:	X; NC_000023.11 (48831096..48835610, complement)

Tissue Specificity

Expressed in brain and pancreas.

Subcellular Localizations

Secreted. Golgi apparatus, trans-Golgi network. A N-terminal processed peptide, probably Big SAAS or Little SAAS, is accumulated in cytoplasmic protein tau deposits in frontotemporal dementia and parkinsonism linked to chromosome 17 (Pick disease), Alzheimer disease and amyotrophic lateral sclerosis-parkinsonism/dementia complex 1 (Guam disease).

Diseases

Pituitary Diseases
Obesity
Nervousness
Diabetes Mellitus
Disease Of Adrenal Medulla
Neurodegenerative Disorders
Insulinoma
Pick Disease Of The Brain
Dementia
Pain
Secondary Parkinson Disease

Pheochromocytoma
Neurofibrillary Tangles
Nerve Degeneration
Glucagonoma
Neurotoxicity Syndromes
Complications Of Diabetes Mellitus

Pathways

Secretory Pathway
Localization
Secretion
Glucose Homeostasis
Cellular Localization
Locomotion
Regulated Secretory Pathway

Eating Behavior

PTMs

Cleavage

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PCSK1N

References

PMID: 10632593 by Fricker L., et al. Identification and characterization of proSAAS, a granin-like neuroendocrine peptide precursor that inhibits prohormone processing.

PMID: 11435430 by Basak A., et al. Inhibitory specificity and potency of proSAAS-derived peptides toward proprotein convertase 1.