KCNMB4 Antibodies

AND KCNMB4 ELISA kits, KCNMB4 Proteins

Many biological assays use antibodies to detect KCNMB4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with KCNMB4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop KCNMB4 antibodies...

We validate the specificity of these antibodies to KCNMB4 by testing them on tissues known to express KCNMB4 positively and negatively. Browse below to find the KCNMB4 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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KCNMB4 Infographic by Boster Bio

All KCNMB4 Products

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Product

Figures

Specificity

Applications

Price

Anti-MaxiK beta KCNMB4 Antibody

6 Q&As

Human, Mouse, Rat

$399
Cat # A06117
100μl

Anti-MaxiK Beta (K119) KCNMB4 Antibody

Human, Mouse, Rat

IHC

$405
Cat # A06117-1
100ul

KCNMB4 (NM_014505) Human Over-expression Lysate

Human

$628
Cat # LS027345
100 µg

KCNMB4 Overview

Facts about Calcium-activated potassium channel subunit beta-4.

KCNMB4 3D structure. Source: alphafold

Calcium-activated potassium channel subunit beta-4 (KCNMB4)

Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity.

Decreases the gating kinetics and calcium sensitivity of the KCNMA1 channel, but with fast deactivation kinetics. May reduce KCNMA1 channel openings at low calcium concentrations but increases channel openings at high calcium concentrations.

Gene Information

Human
Gene Name:	KCNMB4
Uniprot:	Q86W47
Entrez:	27345

Family

Belongs to:

KCNMB (TC 8.A.14.1) family

Alternative Names

BK channel subunit beta-4; BKbeta4; calcium-activated potassium channel subunit beta-4; Calcium-activated potassium channel, subfamily M subunit beta-4; Charybdotoxin receptor subunit beta-4; hbeta4; k(VCA)beta-4; large conductance calcium-dependent potassium ion channel beta 4 subunit; Maxi K channel subunit beta-4; potassium large conductance calcium-activated channel, subfamily M, beta member4; slo-beta-4

Molecular Weight

Mass (kDA):
23.949 kDA

Genomic Context


Human

Location:	12q15
Sequence:	12; NC_000012.12 (70366220..70434292)

Tissue Specificity

Predominantly expressed in brain. In brain, it is expressed in the cerebellum, cerebral cortex, medulla, spinal cord, occipital pole, frontal lobe, temporal lobe, putamen, amygdala, caudate nucleus, corpus callosum, hippocampus, substantia nigra and thalamus. Weakly or not expressed in other tissues.

Subcellular Localizations

Membrane; Multi-pass membrane protein.

Diseases

Epilepsy
Ataxia
Epilepsy, Generalized
Nervous System Disorder
Chorea
Fluid Retention
Tremor, Unspecified
Dyskinetic Syndrome
Dyskinesia, Paroxysmal

Impairment (finding)
Nervousness
Pertussis
Cattle Diseases

Pathways

Secretion
Synaptic Transmission
Osteoblast Proliferation
Localization
Rna Interference

PTMs

Glycoprotein

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/KCNMB4

References

PMID: 10792058 by Meera P., et al. A neuronal beta subunit (KCNMB4) makes the large conductance, voltage- and Ca2+-activated K+ channel resistant to charybdotoxin and iberiotoxin.

PMID: 10828459 by Behrens R., et al. hKCNMB3 and hKCNMB4, cloning and characterization of two members of the large-conductance calcium-activated potassium channel beta subunit family.