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- Table of Contents
Facts about Alpha-parvin.
Plays a role in sprouting angiogenesis and is needed for normal adhesion of vascular smooth muscle cells into endothelial cells during blood vessel growth (By similarity). Plays a role in the reorganization of the actin cytoskeleton, formation of lamellipodia and ciliogenesis.
Human | |
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Gene Name: | PARVA |
Uniprot: | Q9NVD7 |
Entrez: | 55742 |
Belongs to: |
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parvin family |
Actopaxin; alphaParvin; alpha-Parvin; Calponin-like integrin-linked kinase-binding protein; CH-ILKBP; FLJ10793; FLJ12254; FLJ25106; FLJ46049; Matrix-remodeling-associated protein 2; matrix-remodelling associated 2; MXRA2; PARVA; parvin, alpha
Mass (kDA):
42.244 kDA
Human | |
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Location: | 11p15.3 |
Sequence: | 11; NC_000011.10 (12376441..12535356) |
Widely expressed, with highest levels in heart, skeletal muscle, kidney and liver.
Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, myofibril, sarcomere, Z line. Constituent of focal adhesions. Associates with the actin cytoskeleton.
PMID: 11171322 by Olski T.M., et al. Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily.
PMID: 11331308 by Tu Y., et al. A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading.