PARP2 Antibodies

AND PARP2 ELISA kits, PARP2 Proteins

Many biological assays use antibodies to detect PARP2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PARP2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PARP2 antibodies...

We validate the specificity of these antibodies to PARP2 by testing them on tissues known to express PARP2 positively and negatively. Browse below to find the PARP2 antibody that suites your experiment. We have 5 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PARP2 Infographic by Boster Bio

All PARP2 Products

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Product

Figures

Specificity

Applications

Price

Anti-PARP-2 Antibody

4 Q&As

Human, Mouse

ELISA, WB

$399
Cat # A03270-1
100μl

Anti-Poly [ADP-ribose] polymerase 2 PARP2 Antibody

Human, Mouse, Rat

$405
Cat # A03270
100ul

Anti-PARP2 Antibody Picoband®

Human, Rat

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A03270-2
100 μg/vial

Human PARP2 Recombinant Protein

SDS-PAGE, Denatured

$250
Cat # PROTQ9UGN5
Starting from 20ug

Anti-PARP2 Rabbit Monoclonal Antibody

Human, Mouse, Rat

Flow Cytometry, IF, ICC, WB

$370
Cat # M03270-1
100 μl/vial

PARP2 Overview

Facts about Poly [ADP-ribose] polymerase 2.

PARP2 3D structure. Source: alphafold

Poly [ADP-ribose] polymerase 2 (PARP2)

Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin structure and in DNA metabolism (PubMed:10364231, PubMed:28190768). This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway leading to the reparation of DNA strand breaks (PubMed:10364231).

Mediates serine ADP-ribosylation of target proteins after interaction with HPF1; HPF1 conferring serine specificity (PubMed:28190768). .

Gene Information

Human
Gene Name:	PARP2
Uniprot:	Q9UGN5
Entrez:	10038

Family

Belongs to:

No superfamily

Alternative Names

ADP-ribosyltransferase (NAD+; poly(ADP-ribose) polymerase)-like 2; ADPRT-2; ADPRT2pADPRT-2; ADPRTL2EC 2.4.2.30; ADPRTL3; hPARP-2; NAD(+) ADP-ribosyltransferase 2; PARP-2; poly (ADP-ribose) polymerase 2; poly (ADP-ribose) polymerase family, member 2; poly (ADP-ribosyl) transferase-like 2; poly [ADP-ribose] polymerase 2; poly(ADP-ribose) synthetase; Poly[ADP-ribose] synthase 2; poly[ADP-ribose] synthetase 2

Molecular Weight

Mass (kDA):
66.206 kDA

Genomic Context


Human

Location:	14q11.2
Sequence:	14; NC_000014.9 (20343041..20357904)

Tissue Specificity

Widely expressed, mainly in actively dividing tissues. The highest levels are in the brain, heart, pancreas, skeletal muscle and testis; also detected in kidney, liver, lung, placenta, ovary and spleen; levels are low in leukocytes, colon, small intestine, prostate and thymus.

Subcellular Localizations

Nucleus.

Diseases

Neoplasms
Malignant Neoplasms
Genomic Instability
Malignant Neoplasm Of Breast
Malignant Paraganglionic Neoplasm
Fanconi Anemia
Neoplasm Metastasis
Melanoma
Neurodegenerative Disorders
Ataxia
Neoplasms, Experimental
Glioma
Stromal Neoplasm

Mesenchymal Cell Neoplasm
Neoplasm Invasiveness
Infertility
Mitochondrial Damage
Hypokinesia
Leukemia, Myelocytic, Acute
Telomere Shortening

Interacting Proteins

FKBP3
STAC

Pathways

Cell Death
Dna Repair
Cell Cycle
Chromatin Remodeling
Dna Replication
Pathogenesis
Rna Interference
Cell Cycle Checkpoint
Gene Silencing
Fertilization
Double-strand Break Repair
Cell Proliferation
Localization

Autophagy
Programmed Cell Death
Aging
Pigmentation
Hypersensitivity
Neurogenesis
Spermatogenesis

PTMs

Ribosylation

Phosphorylation

Research Areas

Apoptosis
DNA Repair
Hypoxia

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PARP2

References

PMID: 10364231 by Ame J.-C., et al. PARP-2, a novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase.

PMID: 10329013 by Johansson M.; A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues.