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PARP3 Antibodies
AND PARP3 ELISA kits, PARP3 Proteins
Many biological assays use antibodies to detect PARP3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PARP3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PARP3 antibodies...
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PARP3 Infographic by Boster Bio
All PARP3 Products
Product
Figures
Specificity
Applications
Price
Human, Monkey, Mouse, Rat
ELISA, IF, IHC, ICC, WB
$370
Cat # A03762-2
100 µg/vial
Cat # A03762-2
100 µg/vial
PARP3 Overview
Facts about Protein mono-ADP-ribosyltransferase PARP3.
Protein mono-ADP-ribosyltransferase PARP3 (PARP3)
Involved in the base excision repair (BER) pathway, by catalyzing the poly(ADP-ribosyl)ation of a limited number of acceptor proteins involved in chromatin architecture and in DNA metabolism. This modification follows DNA damages and appears as an obligatory step in a detection/signaling pathway resulting in the reparation of DNA strand breaks.
May link the DNA damage surveillance network to the mitotic fidelity checkpoint. Negatively influences the G1/S cell cycle progression without interfering with centrosome duplication.
Gene Information
| Human | |
|---|---|
| Gene Name: | PARP3 |
| Uniprot: | Q9Y6F1 |
| Entrez: | 10039 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 3; ADPRT-3; ADPRT3PADPRT-3; ADPRTL2; ADPRTL3NAD+ ADP-ribosyltransferase 3; EC 2.4.2.30; hPARP-3; IRT1ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 2; NAD(+) ADP-ribosyltransferase 3; pADPRT-3; PARP-3; poly (ADP-ribose) polymerase family, member 3; poly [ADP-ribose] polymerase 3; poly(ADP-ribose) synthetase-3; Poly[ADP-ribose] synthase 3; poly[ADP-ribose] synthetase 3
Molecular Weight
Mass (kDA):
60.089 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p21.2 |
| Sequence: | 3; NC_000003.12 (51942290..51948867) |
Tissue Specificity
Widely expressed; the highest levels are in the kidney, skeletal muscle, liver, heart and spleen; also detected in pancreas, lung, placenta, brain, leukocytes, colon, small intestine, ovary, testis, prostate and thymus.
Subcellular Localizations
Nucleus. Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Almost exclusively localized in the nucleus and appears in numerous small foci and a small number of larger foci whereas a centrosomal location has not been detected (PubMed:16924674). In response to DNA damage, localizes to sites of double-strand break (PubMed:21270334). Preferentially localized to the daughter centriole (PubMed:10329013).
Diseases
- Malignant Neoplasms
- Neoplasms
- Carcinoma
- Genomic Instability
- Carcinoma, Transitional Cell
- Melanoma
- Neurodegenerative Disorders
- Tumor Progression
- Malignant Neoplasm Of Lung
- Malignant Neoplasm Of Urinary Bladder
- Telomere Shortening
- Tumor Angiogenesis
- Pancreatic Neoplasm
Pathways
- Dna Repair
- Cell Death
- Pathogenesis
- Base-excision Repair
- Induction Of Apoptosis
- Pigmentation
- Neurogenesis
- Localization
- Double-strand Break Repair
- Cell Fate Specification
PTMs
- Ribosylation
Research Areas
- Apoptosis
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PARP3
bosterbio.com/bosterbio-gene-info-cards/PARP3
References
PMID: 10329013 by Johansson M.; A human poly(ADP-ribose) polymerase gene family (ADPRTL): cDNA cloning of two novel poly(ADP-ribose) polymerase homologues.
PMID: 12640039 by Augustin A., et al. PARP-3 localizes preferentially to the daughter centriole and interferes with the G1/S cell cycle progression.