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- Table of Contents
Facts about Protein mono-ADP-ribosyltransferase PARP10.
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Human | |
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Gene Name: | PARP10 |
Uniprot: | Q53GL7 |
Entrez: | 84875 |
Belongs to: |
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No superfamily |
EC 2.4.2.30; FLJ14464; PARP-10; poly (ADP-ribose) polymerase family, member 10; poly [ADP-ribose] polymerase 10
Mass (kDA):
109.998 kDA
Human | |
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Location: | 8q24.3 |
Sequence: | 8; NC_000008.11 (143977158..143986460, complement) |
Highly expressed in spleen and thymus. Intermediate levels in liver, kidney, pancreas, prostate, testis, ovary, intestine, and leukocytes. Low expression in heart, brain, placenta, lung, skeletal muscle, and colon.
Nucleus, nucleolus. Cytoplasm. Shuttles between the nuclear and cytoplasmic compartment (PubMed:15674325). A subpopulation concentrates in the nucleolus during late G1/S phase (PubMed:15674325).
PMID: 15674325 by Yu M., et al. PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation.
PMID: 16455663 by Chou H.Y., et al. CDK-dependent activation of poly(ADP-ribose) polymerase member 10 (PARP10).