PARG Antibodies

AND PARG ELISA kits, PARG Proteins

Many biological assays use antibodies to detect PARG, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PARG in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PARG antibodies...

We validate the specificity of these antibodies to PARG by testing them on tissues known to express PARG positively and negatively. Browse below to find the PARG antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PARG Infographic by Boster Bio

All PARG Products

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Product

Figures

Specificity

Applications

Price

Anti-PARG Antibody

Human, Mouse, Rat

$405
Cat # A04301
100ul

Anti-PARG Mouse Monoclonal Antibody [Clone ID: OTI6F4]

Human, Mouse, Rat

IHC, WB

$523
Cat # M04301
100 µl

PARG (NM_003631) Human Over-expression Lysate

Human

$628
Cat # LS008505
100 µg

PARG Overview

Facts about Poly(ADP-ribose) glycohydrolase.

PARG 3D structure. Source: alphafold

Poly(ADP-ribose) glycohydrolase (PARG)

Poly(ADP-ribose) synthesized after DNA damage is only present transiently and is quickly degraded by poly(ADP-ribose) glycohydrolase (PubMed:23102699). PARG acts both as an endo- and exoglycosidase, releasing PAR of different length as well as ADP- ribose monomers (PubMed:23102699).

Required for retinoid acid- dependent gene transactivation, probably by dePARsylating histone demethylase KDM4D, allowing chromatin derepression in RAR- dependent gene promoters (PubMed:23102699). Involved in the synthesis of ATP in the nucleus, together with PARP1, NMNAT1 and NUDT5 (PubMed:27257257).

Gene Information

Human
Gene Name:	PARG
Uniprot:	Q86W56
Entrez:	8505

Family

Belongs to:

poly(ADP-ribose) glycohydrolase family

Alternative Names

EC 3.2.1.143; FLJ54459; FLJ60257; FLJ60456; PARG; PARG99; poly (ADP-ribose) glycohydrolase; poly(ADP-ribose) glycohydrolase 60 kDa isoform; poly(ADP-ribose) glycohydrolase

Molecular Weight

Mass (kDA):
111.11 kDA

Genomic Context


Human

Location:	10q11.23
Sequence:	10; NC_000010.11 (49818274..49942027, complement)

Tissue Specificity

Ubiquitously expressed.

Subcellular Localizations

[Isoform 1]: Nucleus. Colocalizes with PCNA at replication foci (PubMed:21398629). Relocalizes to the cytoplasm in response to DNA damage (PubMed:16460818).; [Isoform 2]: Cytoplasm. Translocates to the nucleus in response to DNA damage.; [Isoform 3]: Cytoplasm.; [Isoform 4]: Cytoplasm. Mitochondrion.; [Isoform 5]: Mitochondrion matrix.

Diseases

Malignant Neoplasms
Neoplasms
Inflammation
Genotoxic Stress
Ischemia
Carcinoma
Genomic Instability
Carcinogenesis
Infarction
Tissue Adhesions
Brain Ischemia
Reperfusion Injury

Inflammatory Response
Brain Injuries
Diabetes Mellitus
Cerebrovascular Accident
Arterial Occlusion
Malignant Neoplasm Of Breast
Malignant Tumor Of Colon

Pathways

Cell Death
Dna Repair
Localization
Cell Division
Cell Differentiation
Mitosis
Rna Interference
Dna Replication
Inflammatory Response
Cell Cycle
Necrotic Cell Death
Cell Growth
Chromatin Remodeling

Pathogenesis
Transport
Gene Silencing
Aging
Proteolysis
Translation
Cell Adhesion

PTMs

Cleavage
Phosphorylation
Ribosylation

Methylation
Carboxylation
Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PARG

References

PMID: 14527731 by Meyer R.G., et al. Human poly(ADP-ribose) glycohydrolase (PARG) gene and the common promoter sequence it shares with inner mitochondrial membrane translocase 23 (TIM23).

PMID: 15212953 by Meyer-Ficca M.L., et al. Human poly(ADP-ribose) glycohydrolase is expressed in alternative splice variants yielding isoforms that localize to different cell compartments.