CNTNAP1 Antibodies

AND CNTNAP1 ELISA kits, CNTNAP1 Proteins

Many biological assays use antibodies to detect CNTNAP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with CNTNAP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop CNTNAP1 antibodies...

We validate the specificity of these antibodies to CNTNAP1 by testing them on tissues known to express CNTNAP1 positively and negatively. Browse below to find the CNTNAP1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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CNTNAP1 Infographic by Boster Bio

All CNTNAP1 Products

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Specificity

Applications

Price

Anti-Caspr Monoclonal Antibody

1 Citations 7 Q&As

Human, Mouse, Rat

IHC, WB

$370
Cat # M08617
100 μl

Caspr (CNTNAP1) (NM_003632) Human Over-expression Lysate

Human

$960
Cat # LS008506
100 µg

CNTNAP1 Overview

Facts about Contactin-associated protein 1.

CNTNAP1 3D structure. Source: alphafold

Contactin-associated protein 1 (CNTNAP1)

Required, with CNTNAP2, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains essential for saltatory conduction of nerve impulses in myelinated nerve fibers.

Demarcates the paranodal region of the axo-glial junction. In association with contactin involved in the signaling between axons and myelinating glial cells.

Gene Information

Human
Gene Name:	CNTNAP1
Uniprot:	P78357
Entrez:	8506

Family

Belongs to:

neurexin family

Alternative Names

Caspr; Caspr1; CASPRcaspr1; CNTNAP; CNTNAP1; contactin associated protein 1; neurexin 4; Neurexin IV; neurexin-4; NRXN4contactin-associated protein 1; p190

Molecular Weight

Mass (kDA):
156.267 kDA

Genomic Context


Human

Location:	17q21.2
Sequence:	17; NC_000017.11 (42679767..42699993)

Tissue Specificity

Predominantly expressed in brain. Weak expression detected in ovary, pancreas, colon, lung, heart, intestine and testis.

Subcellular Localizations

Membrane; Single-pass type I membrane protein. Cell junction, paranodal septate junction.

Diseases

Tissue Adhesions
Nervousness
Demyelination
Neoplasms
Sclerosis
Malignant Neoplasms
Multiple Sclerosis
Demyelinating Diseases
Spinal Cord Injuries
Ataxia
Malnutrition
Malignant Neoplasm Of Breast
Carcinoma

Mammary Neoplasms
Charcot-marie-tooth Disease
Peripheral Neuropathy
Nerve Degeneration
Paresis
Cholangiocarcinoma
Neoplasm Metastasis

Interacting Proteins

NCK1

Pathways

Localization
Cell Adhesion
Myelination
Transport
Regeneration
Cell Recognition
Pathogenesis
Intracellular Transport
Cell Proliferation
Blood Vessel Development
Aging
Proteolysis
Immune Response

Glycosylation
Synaptic Transmission
Nerve Development
Organ Development
Gliogenesis
Cell Death
Metabolic Process

PTMs

Glycosylation

Cleavage

Gpi Anchoring

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/CNTNAP1

References

PMID: 9118959 by Peles E., et al. Identification of a novel contactin-associated transmembrane receptor with multiple domains implicated in protein-protein interactions.

PMID: 24319099 by Laquerriere A., et al. Mutations in CNTNAP1 and ADCY6 are responsible for severe arthrogryposis multiplex congenita with axoglial defects.

1 Publications of Boster CNTNAP1 Antibodies & ELISA Kits

PubMed ID: 25682129, Up-regulation of P2X7 receptors mediating proliferation of Schwann cells after ...

*More publications can be found for each product on its corresponding product page