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PARD3 Antibodies
AND PARD3 ELISA kits, PARD3 Proteins
Many biological assays use antibodies to detect PARD3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PARD3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PARD3 antibodies...
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PARD3 Infographic by Boster Bio
All PARD3 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A01897-2
100 μg/vial
Cat # A01897-2
100 μg/vial
PARD3 Overview
Facts about Partitioning defective 3 homolog.
Partitioning defective 3 homolog (PARD3)
Adapter protein involved in cell cell division and cell polarization processes (PubMed:27925688, PubMed:10954424). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688).
Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | PARD3 |
| Uniprot: | Q8TEW0 |
| Entrez: | 56288 |
Family
| Belongs to: |
|---|
| PAR3 family |
Alternative Names
ASIP; Baz; Bazooka; FLJ21015; par-3 partitioning defective 3 homolog (C. elegans); PAR3; PAR3A; PAR3C.elegans) homolog; PARD3; SE2-5L16; SE2-5LT1; SE2-5T2
Molecular Weight
Mass (kDA):
151.423 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 10p11.22-p11.21 |
| Sequence: | 10; NC_000010.11 (34109560..34815325, complement) |
Tissue Specificity
Widely expressed.
Subcellular Localizations
Cytoplasm. Endomembrane system. Cell junction. Cell junction, tight junction. Cell junction, adherens junction. Cell membrane. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Localized along the cell-cell contact region. Colocalizes with PARD6A and PRKCI at epithelial tight junctions. Colocalizes with the cortical actin that overlays the meiotic spindle during metaphase I and metaphase II. Colocalized with SIRT2 in internode region of myelin sheat (By similarity). Presence of KRIT1, CDH5 and RAP1B is required for its localization to the cell junction.
Diseases
- Neoplasms
- Malignant Neoplasms
- Tissue Adhesions
- Cell Transformation, Neoplastic
- Carcinoma
- Neoplasm Metastasis
- Inflammation
- Intestinal Diseases
- Malignant Paraganglionic Neoplasm
- Cell Invasion
- Inflammatory Bowel Diseases
- Celiac Disease
- Carcinogenesis
Interacting Proteins
- CDH5
- CTNNB1
- F11R
- PARD6A
- PARD6B
- Pard6b
- PARD6G
- PNMA1
- PRKCI
- Prkci
Pathways
- Localization
- Cell Division
- Cell Migration
- Establishment Of Cell Polarity
- Asymmetric Cell Division
- Cell Adhesion
- Maintenance Of Cell Polarity
- Chemotaxis
- Cell Cycle
- Rna Interference
- Secretion
- Myelination
- Transport
PTMs
- Phosphorylation
- Cleavage
- Carboxylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PARD3
bosterbio.com/bosterbio-gene-info-cards/PARD3
References
PMID: 10934474 by Joberty G., et al. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42.
PMID: 11642408 by Fang C.M., et al. Down-regulated expression of atypical PKC-binding domain deleted asip isoforms in human hepatocellular carcinomas.