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- Table of Contents
Facts about Pappalysin-2.
Metalloproteinase which specifically cleaves insulin- like growth factor binding protein (IGFBP)-5 at the'163-Ser-
.Human | |
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Gene Name: | PAPPA2 |
Uniprot: | Q9BXP8 |
Entrez: | 60676 |
Belongs to: |
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peptidase M43B family |
EC 3.4.24.-; PAPPA2; PAPP-A2; PAPP-A2pappalysin-2; pappalysin 2; Pappalysin2; Pappalysin-2; PAPPE; PAPP-E; PLAC3; placenta-specific 3; pregnancy-associated plasma preproprotein-A2; Pregnancy-associated plasma protein A2; Pregnancy-associated plasma protein E1
Mass (kDA):
198.539 kDA
Human | |
---|---|
Location: | 1q25.2 |
Sequence: | 1; NC_000001.11 (176463159..176845601) |
Expressed abundantly in placenta, and non- pregnant mammary gland with low expression in the kidney, fetal brain and pancreas.
Secreted.
PMID: 11264294 by Overgaard M.T., et al. Pregnancy-associated plasma protein-A2 (PAPP-A2), a novel insulin- like growth factor-binding protein-5 proteinase.
PMID: 11597188 by Page N.M., et al. The characterization of pregnancy associated plasma protein-E and the identification of an alternative splice variant.