PACS1 Antibodies

AND PACS1 ELISA kits, PACS1 Proteins

Many biological assays use antibodies to detect PACS1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PACS1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PACS1 antibodies...

We validate the specificity of these antibodies to PACS1 by testing them on tissues known to express PACS1 positively and negatively. Browse below to find the PACS1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PACS1 Infographic by Boster Bio

All PACS1 Products

Product

Figures

Specificity

Applications

Price

Anti-PACS-1 Antibody

6 Q&As

Human

$341
Cat # A06811
100 µg

Anti-PACS1 Antibody

Human, Mouse, Rat

ELISA, IF, IHC-P, WB

$449
Cat # A06811-1
0.1 mg

PACS1 (NM_018026) Human Over-expression Lysate

Human

$628
Cat # LS055690
100 µg

PACS1 Overview

Facts about Phosphofurin acidic cluster sorting protein 1.

PACS1 3D structure. Source: alphafold

Phosphofurin acidic cluster sorting protein 1 (PACS1)

Coat protein that's involved in the localization of trans-Golgi network (TGN) membrane proteins which contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin- coated membrane pits.

Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN. .

Gene Information

Human
Gene Name:	PACS1
Uniprot:	Q6VY07
Entrez:	55690

Family

Belongs to:

PACS family

Alternative Names

cytosolic sorting protein PACS-1; FLJ10209; KIAA1175; PACS-1; phosphofurin acidic cluster sorting protein 1

Molecular Weight

Mass (kDA):
104.898 kDA

Genomic Context


Human

Location:	11q13.1-q13.2
Sequence:	11; NC_000011.10 (66070272..66244744)

Subcellular Localizations

Golgi apparatus, trans-Golgi network. Localizes in the perinuclear region, probably the TGN.

Diseases

Hiv Infections
Immunologic Deficiency Syndromes
Malignant Neoplasms
Acquired Immunodeficiency Syndrome
Cytomegalovirus Infections
Kidney Diseases
Melanoma
Neurodegenerative Disorders
Uterine Cervical Neoplasm
Dementia
Anosmia
Ataxia

Malignant Neoplasm Of Liver
Malignant Tumor Of Cervix
Neoplasms
Nervousness
Foreign Body Of Body Structure
Steroid Sulfatase Deficiency Disease

Interacting Proteins

CSNK2B
GGA3
IGF2R

Pathways

Localization
Transport
Secretory Pathway
Endocytosis
Protein Transport
Pathogenesis
Clathrin-mediated Endocytosis
Cell Death

Regulated Secretory Pathway
Ion Homeostasis

PTMs

Phosphorylation
Dephosphorylation

Myristoylation
Cleavage

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PACS1

References

PMID: 11331585 by Crump C.M., et al. PACS-1 binding to adaptors is required for acidic cluster motif- mediated protein traffic.

PMID: 10707087 by Piguet V., et al. HIV-1 Nef protein binds to the cellular protein PACS-1 to downregulate class I major histocompatibility complexes.