Proteasomal ATPase-associated factor 1 (PAAF1)

Inhibits proteasome 26S meeting and proteolytic activity by impairing the institution of the 19S regulatory complex with the 20S core. In the event of HIV-1 infection, recruited by viral Tat into the HIV-1 promoter, where it promotes the recruitment of 19S regulatory complex via dissociation of the proteasome 26S.

This presumably promotes provirus transcription efficiency. Protects SUPT6H from proteasomal degradation.