OPA1 Antibodies

AND OPA1 ELISA kits, OPA1 Proteins

Many biological assays use antibodies to detect OPA1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with OPA1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop OPA1 antibodies...

We validate the specificity of these antibodies to OPA1 by testing them on tissues known to express OPA1 positively and negatively. Browse below to find the OPA1 antibody that suites your experiment. We have 6 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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OPA1 Infographic by Boster Bio

All OPA1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-OPA1 Antibody Picoband®

17 Q&As

Human, Mouse, Rat

Flow Cytometry, IF, IHC, IHC-F, ICC, WB

$370
Cat # PB9731
100 μg/vial

Anti-OPA1 Monoclonal Antibody

16 Q&As

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M00508
100 μl

Anti-OPA1 Antibody

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$405
Cat # A00508
100ul

Anti-Fruit fly Opa1 Antibody

Fruit fly

$470
Cat # DZ41316
200 μl/vial

OPA1 (NM_015560) Human Over-expression Lysate

Human

$628
Cat # LS004976
100 µg

Anti-OPA1 Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A00508-1
100 µg/vial

OPA1 Overview

Facts about Dynamin-like 120 kDa protein, mitochondrial.

OPA1 3D structure. Source: alphafold

Dynamin-like 120 kDa protein, mitochondrial (OPA1)

Dynamin-related GTPase that's essential for normal mitochondrial morphology by regulating the balance between mitochondrial fusion and mitochondrial fission (PubMed:16778770, PubMed:17709429, PubMed:20185555, PubMed:24616225, PubMed:28746876). Coexpression of isoform 1 with shorter alternative products is necessary for optimal activity in promoting mitochondrial fusion (PubMed:17709429).

Binds lipid membranes enriched in negatively charged phospholipids, such as cardiolipin, and promotes membrane tubulation (PubMed:20185555). The intrinsic GTPase activity is reduced, and is strongly increased by interaction with lipid membranes (PubMed:20185555).

Gene Information

Human
Gene Name:	OPA1
Uniprot:	O60313
Entrez:	4976

Family

Belongs to:

TRAFAC class dynamin-like GTPase superfamily

Alternative Names

BERHS; EC 3.6.5.5; FLJ12460; KIAA0567dynamin-like 120 kDa protein, mitochondrial; LargeG; lilr3; MGM1; mitochondrial dynamin-like GTPase; MTDPS14; NPG; NPGlargeG; NTG; NTGmitochondrial dynamin-like 120 kDa protein; OPA1; optic atrophy 1 (autosomal dominant); Optic atrophy protein 1

Molecular Weight

Mass (kDA):
111.631 kDA

Genomic Context


Human

Location:	3q29
Sequence:	3; NC_000003.12 (193593144..193697811)

Tissue Specificity

Highly expressed in retina. Also expressed in brain, testis, heart and skeletal muscle. Isoform 1 expressed in retina, skeletal muscle, heart, lung, ovary, colon, thyroid gland, leukocytes and fetal brain. Isoform 2 expressed in colon, liver, kidney, thyroid gland and leukocytes. Low levels of all isoforms expressed in a variety of tissues.

Subcellular Localizations

Mitochondrion inner membrane; Single-pass membrane protein. Mitochondrion intermembrane space. Mitochondrion membrane. Detected at contact sites between endoplamic reticulum and mitochondrion membranes.