Oligophrenin-1 Antibodies

AND OPHN1 ELISA kits, Oligophrenin-1 Proteins

Many biological assays use antibodies to detect Oligophrenin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Oligophrenin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Oligophrenin-1 antibodies...

We validate the specificity of these antibodies to Oligophrenin-1 by testing them on tissues known to express OPHN1 positively and negatively. Browse below to find the OPHN1 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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OPHN1 Infographic by Boster Bio

All OPHN1 Products

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Product

Figures

Specificity

Applications

Price

OPHN1 (NM_002547) Human Recombinant Protein

$813
Cat # PROTO60890
20 µg

OPHN1 (NM_002547) Human Over-expression Lysate

Human

$960
Cat # LS004983
100 µg

OPHN1 Overview

Facts about Oligophrenin-1.

OPHN1 3D structure. Source: alphafold

Oligophrenin-1 (OPHN1)

Stimulates GTP hydrolysis of All Members of the Rho family.
Its action on RHOA activity and signaling is implicated in growth and stabilization of dendritic spines, and therefore in synaptic function.

Crucial for the stabilization of AMPA receptors at postsynaptic sites. Critical for the regulation of synaptic vesicle endocytosis at presynaptic terminals.

Gene Information

Human
Gene Name:	OPHN1
Uniprot:	O60890
Entrez:	4983

Family

Belongs to:

No superfamily

Alternative Names

ARHGAP41; mental retardation, X-linked 60; MRX60; oligophrenin 1; oligophrenin-1; oligophrenin-1, Rho-GTPase activating protein; OPN1

Molecular Weight

Mass (kDA):
91.641 kDA

Genomic Context


Human

Location:	Xq12
Sequence:	X;

Tissue Specificity

Expressed in brain.

Subcellular Localizations

Cell junction, synapse, postsynapse. Cell junction, synapse, presynapse. Cell projection, axon. Cell projection, dendritic spine. Cell projection, dendrite. Cytoplasm.

Diseases

Congenital Cerebellar Hypoplasia
Hypoplasia
Fragile X Syndrome
Impaired Cognition
Nervousness
Epilepsy
Ataxia
Malignant Neoplasms
Neoplasms
Congenital Abnormality
Muscle Hypotonia

Genetic Diseases, X-linked
Autistic Disorder
Malignant Neoplasm Of Stomach
Stomach Neoplasms
Strabismus
Depressive Disorder

Pathways

Dendritic Spine Morphogenesis
Pathogenesis
Synaptic Transmission
Endocytosis
Transport
Translation
Localization
Synapse Maturation
Cell Adhesion
Clathrin-mediated Endocytosis
Long-term Synaptic Potentiation
Cell Migration
Regulation Of Gene Expression

Synaptic Vesicle Transport
Cytoskeleton Organization
Reverse Transcription
Cell Cycle
Cognition
Diaphragm Development
Vesicle Transport

PTMs

Ribosylation

Research Areas

Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/OPHN1

References

PMID: 9582072 by Billuart P., et al. Oligophrenin-1 encodes a rhoGAP protein involved in X-linked mental retardation.

PMID: 10439959 by Tentler D., et al. Deletion including the oligophrenin-1 gene associated with enlarged cerebral ventricles, cerebellar hypoplasia, seizures and ataxia.