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Oma1 Antibodies
AND Oma1 ELISA kits, Oma1 Proteins
Many biological assays use antibodies to detect Oma1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Oma1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Oma1 antibodies...
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Oma1 Overview
Facts about Metalloendopeptidase OMA1, mitochondrial.
Metalloendopeptidase OMA1, mitochondrial (Oma1)
Metalloprotease that is part of the quality management system in the inner membrane of mitochondria. Following stress conditions that cause loss of mitochondrial membrane potential, mediates cleavage of OPA1 in S1 position, resulting in OPA1 inactivation and negative regulation of mitochondrial fusion (PubMed:22433842, PubMed:24616225, PubMed:26785494).
May also cleave UQCC3 under these conditions. Its role in mitochondrial excellent control is vital for regulating lipid metabolism as well as to maintain body temperature and energy expenditure under cold-stress problems.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Oma1 |
| Uniprot: | Q9D8H7 |
| Entrez: | 67013 |
Family
| Belongs to: |
|---|
| peptidase M48 family |
Alternative Names
2010001O09Rik; DAB1; EC 3.4.24.-; metalloprotease related protein 1; Metalloprotease-related protein 1; MPRP1; MPRP-1mitochondrial; OMA1 homolog, zinc metallopeptidase (S. cerevisiae); overlapping activity with M-AAA protease; YKR087C; ZMPOMA1
Molecular Weight
Mass (kDA):
58.878 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 4|4 C6 |
| Sequence: | 4; |
Diseases
- Aortic Aneurysm, Abdominal
- Optic Atrophy
- Obesity
- Steatohepatitis
- Neurodegenerative Disorders
- Optic Atrophy, Autosomal Dominant
- Atrophy
- Steatosis
Pathways
- Proteolysis
- Mitochondrial Fusion
- Translation
- Membrane Fusion
- Pathogenesis
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Oma1
bosterbio.com/bosterbio-gene-info-cards/Oma1
References
PMID: 20038678 by Ehses S., et al. Regulation of OPA1 processing and mitochondrial fusion by m-AAA protease isoenzymes and OMA1.
PMID: 22433842 by Quiros P.M., et al. Loss of mitochondrial protease OMA1 alters processing of the GTPase OPA1 and causes obesity and defective thermogenesis in mice.