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ORAI1 Antibodies
AND ORAI1 ELISA kits, ORAI1 Proteins
Many biological assays use antibodies to detect ORAI1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with ORAI1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop ORAI1 antibodies...
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ORAI1 Infographic by Boster Bio
All ORAI1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00909
100 μg/vial
Cat # A00909
100 μg/vial
Human, Mouse, Rat
ELISA, IF, IHC-P, WB
$524
Cat # M00909
0.1 mg
Cat # M00909
0.1 mg
ORAI1 Overview
Facts about Calcium release-activated calcium channel protein 1.
Calcium release-activated calcium channel protein 1 (ORAI1)
Ca(2+) release-activated Ca(2+) (CRAC) channel subunit that mediates Ca(2+) influx after depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, STIM1 (PubMed:16582901, PubMed:16645049, PubMed:16733527, PubMed:16766533, PubMed:16807233, PubMed:19249086, PubMed:23307288, PubMed:24351972, PubMed:24591628, PubMed:28219928). CRAC channels are the most important pathway for Ca(2+) influx in T-cells and encourage the immune response to pathogens by activating the transcription factor NFAT (PubMed:16582901).
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Gene Information
| Human | |
|---|---|
| Gene Name: | ORAI1 |
| Uniprot: | Q96D31 |
| Entrez: | 84876 |
Family
| Belongs to: |
|---|
| Orai family |
Alternative Names
CRACM1; CRACM1ORAT1; FLJ14466; ORAI calcium release-activated calcium modulator 1; Orai1; ORAT1; Protein orai-1; TMEM142A; TMEM142Acalcium release-activated calcium modulator 1; Transmembrane protein 142Acalcium release-activated calcium channel protein 1
Molecular Weight
Mass (kDA):
32.668 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q24.31 |
| Sequence: | 12; NC_000012.12 (121626550..121642040) |
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Isoform beta is more mobile in the plasma membrane (PubMed:23307288). Colocalizes with STIM1 at the cell membrane (PubMed:27185316).
Diseases
- Immunologic Deficiency Syndromes
- Malignant Neoplasms
- Severe Combined Immunodeficiency
- Neoplasms
- Thrombosis
- Inflammation
- Tissue Adhesions
- Malignant Neoplasm Of Breast
- Autoimmune Diseases
- Thrombus
- Neoplasm Metastasis
- Mammary Neoplasms
- Asthma
Interacting Proteins
- ATP2C2
- CRACR2A
- ORAI3
- STIM1
- TRPC1
- TRPC3
- Trpc6
Pathways
- Store-operated Calcium Entry
- Cell Proliferation
- Localization
- Secretion
- Lymphocyte Activation
- Rna Interference
- Cell Activation
- Cell Migration
- Immune Response
- Pathogenesis
- Platelet Activation
- T Cell Activation
- Cell Cycle
PTMs
- Phosphorylation
- Glycosylation
- Biotinylation
- Cleavage
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/ORAI1
bosterbio.com/bosterbio-gene-info-cards/ORAI1
References
PMID: 16147976 by Feske S., et al. A severe defect in CRAC Ca2+ channel activation and altered K+ channel gating in T cells from immunodeficient patients.
PMID: 16766533 by Soboloff J., et al. Orai1 and STIM reconstitute store-operated calcium channel function.