OGT Antibodies

AND OGT ELISA kits, OGT Proteins

Many biological assays use antibodies to detect OGT, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with OGT in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop OGT antibodies...

We validate the specificity of these antibodies to OGT by testing them on tissues known to express OGT positively and negatively. Browse below to find the OGT antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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OGT Infographic by Boster Bio

All OGT Products

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Product

Figures

Specificity

Applications

Price

Anti-OGT/O-Linked N-Acetylglucosamine Transferase Antibody Picoband®

16 Q&As

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # PB9767
100 μg/vial

Anti-OGT Monoclonal Antibody

16 Q&As

Human, Mouse, Rat

Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # M00474
100 μl

Anti-OGT Antibody

Human, Mouse, Rat

$405
Cat # A00474
100ul

OGT (NM_181672) Human Over-expression Lysate

Human

$628
Cat # LS008473
100 µg

OGT Overview

Facts about UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit.

OGT 3D structure. Source: alphafold

UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT)

Catalyzes the transfer of one N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta- linked N-acetylglucosamine (O-GlcNAc) (PubMed:26678539, PubMed:23103939, PubMed:21240259, PubMed:21285374, PubMed:15361863). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1.

Can regulate their mobile processes via cross-talk between glycosylation and phosphorylation or by changing proteolytic processing (PubMed:21285374). Likely by glycosylating KMT2E/MLL5, stabilizes KMT2E/MLL5 by preventing its ubiquitination (PubMed:26678539).

Gene Information

Human
Gene Name:	OGT
Uniprot:	O15294
Entrez:	8473

Family

Belongs to:

glycosyltransferase 41 family

Alternative Names

EC 2.4.1; EC 2.4.1.255 ; FLJ23071; HRNT1; MGC22921; O-GlcNAc transferase p110 subunit; O-GlcNAc transferase subunit p110; OGlcNAc Transferase; O-GlcNAc Transferase; O-GLCNAC; OGT; O-linked N-acetylglucosamine (GlcNAc) transferase(UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase); O-linked N-acetylglucosamine transferase 110 kDa subunit; UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDasubunit; uridinediphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase

Molecular Weight

Mass (kDA):
116.925 kDA

Genomic Context


Human

Location:	Xq13.1
Sequence:	X; NC_000023.11 (71533104..71575892)

Tissue Specificity

Highly expressed in pancreas and to a lesser extent in skeletal muscle, heart, brain and placenta. Present in trace amounts in lung and liver.

Subcellular Localizations

Nucleus. Cytoplasm. Predominantly localizes to the nucleus.; [Isoform 2]: Mitochondrion. Membrane. Associates with the mitochondrial inner membrane.; [Isoform 3]: Cytoplasm. Nucleus. Cell membrane. Mitochondrion membrane. Cell projection. Mostly in the nucleus. Retained in the nucleus via interaction with HCFC1 (PubMed:21285374). After insulin induction, translocated from the nucleus to the cell membrane via phosphatidylinositide binding. Colocalizes with AKT1 at the plasma membrane. TRAK1 recruits this protein to mitochondria. In the absence of TRAK1, localizes in cytosol and nucleus (By simi