Neuropilin-2 Antibodies

Neuropilin-2 (NRP2)

High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF. .

Gene Information

Human
Gene Name:	NRP2
Uniprot:	O60462
Entrez:	8828

Family

Belongs to:
neuropilin family

Alternative Names

MGC126574; neuropilin 2; Neuropilin2; Neuropilin-2; neuropilin-2a(22); neuropilin-2b(0); NP2; NPN 2; NPN2; PRO2714; receptor for VEGF165 and semaphorins class3; Vascular endothelial cell growth factor 165 receptor 2; vascular endothelial growth factor-165 receptor 2; VEGF1265R2; VEGF165R2neuropilin-2a(17)

Molecular Weight

Mass (kDA):
104.831 kDA

Genomic Context

Human
Location:	2q33.3
Sequence:	2; NC_000002.12 (205682500..205798131)

Subcellular Localizations

Membrane; Single-pass type I membrane protein.; [Isoform s9]: Secreted.

Diseases

• Neoplasms
• Tumor Angiogenesis
• Malignant Neoplasms
• Pathologic Neovascularization
• Neoplasm Metastasis
• Tumor Progression
• Tissue Adhesions
• Carcinoma
• Nervousness
• Melanoma
• Crest Syndrome
• Hypoxia

• Cell Invasion
• Malignant Neoplasm Of Breast
• Malignant Tumor Of Colon
• Mammary Neoplasms
• Inflammation
• Malignant Paraganglionic Neoplasm
• Malignant Neoplasm Of Lung

Pathways

• Angiogenesis
• Axon Guidance
• Cell Migration
• Cell Adhesion
• Endothelial Cell Migration
• Lymphangiogenesis
• Chemotaxis
• Nucleosome Assembly
• Localization
• Rna Interference
• Segmentation
• Cell Proliferation
• Pathogenesis

• Blood Vessel Development
• Dna Methylation
• Dna Repair
• Receptor Internalization
• Neural Crest Cell Migration
• Gene Silencing
• Immune Response

PTMs

• Phosphorylation
• Methylation
• Demethylation

• Nitration
• Glycosylation
• Acetylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NRP2

Best Uses Of The NRP2 Marker

The NRP2 indicator is a diagnostic tool that can be used to identify NRP2-associated diseases. This biomarker belongs to the HRS-NRP2 group. Its presence is an indication of a medical condition. In addition to detecting NRP2-associated diseases, it can also be used to monitor the presence of certain pathogens, including LCMV.

NRP2 Marker

NRP2 is a protein that inhibits the maturation of early to late phagosomes in macrophages. The maturation phagosomes are affected by NRP2's deletion or knockdown. NRP2 is found downstream of Rab5, and NRP2 can cause increased vesicles to be detected with Rab5 in the absence of NRP2.

The NRP2 gene is expressed in human thymic DP T cells. (CD4 +CD8+T cells). It is found in microglia as well as dendritic, and microglia cells. The marker is useful for identifying tumor cells and other inflammatory disorders. This protein is expressed in a variety cell types, including cancer, inflammation diseases, aging and infectious diseases.

NRP2, which is an enzyme that plays a part in the maturation of phagosomes and their degradation, regulates phagosome maturation. It is an important component of the regulation of phagosome maturity. Knockdowns of NRP1 result in a decrease in phagosome maturation and reduced cargo uptake. Moreover, depletion of NRP1 causes a phagosome maturation phenotype.

NRP2 is used often to identify cancer cells. NRP2 isn't expressed in normal monocytes, bone marrow precursors, or macrophages. However, it can be detected in macrophages if they are injected with GM–CSF or M–CSF. It is useful in identifying tumor cells in the pancreas. The NRP2 marker helps to determine the function tumor cells in the pancreas.

Infection by LCMV

The NRP2 marker, which is used to detect cytomegalovirus infections, has been identified as a promising tool in the detection of LCMV. NRP2 a novel viral polyprotein expressed in plasma membrane is capable of recognizing two subtypes. The virus can infect epithelial cells through a pentamer complex that consists of three gH proteins and two gL proteins.

The NRP2 RNAbinding protein (RNP), is the minimum unit for LCMV infectivity. Regulators that aid replication are found in the viral genome. Gene junctions contain conserved transcript signals. The viral genome is transscribed and replicated in infected cells' cell cytoplasm via an infectious ribonucleoprotein protein complex made up of genomic RNA and N and P proteins. The P protein is always associated to the NRP2 protein.

The NRP2 mRNA is highly sensitive to LCMV. NRP2 genes are highly conserved in humans. This means that NRP2 markers can be used to identify the most effective drug to treat LCMV infections in many different ways. It is likely to become the standard marker of LCMV. There are several other uses for the NRP2 mRNA, and Boster Bio will continue to work on these applications.

This study suggests that the NRP2 gene can be used to identify the best ELISA or cytokine ELISPOT tests for the detection LCMV. The NRP2 gene can be used to identify IL-10-secreting cells that are critical for the treatment of LCMV. Scientists in America discovered the NRP2 Gene.

The NRP2 gene has an interesting history. It has been linked to several viral infections, including LCMV. This is due to the long-lasting, memory-rich CD4 T-cell reaction that acute viral infections trigger. The CD4-T-cell response is composed of three phases. They are activated in the first week following infection. The CD4 T-cells become memory cells after a month and remain in this state for 300 consecutive days.

NRP2 is also useful in detecting splenic splenicCD4 T cells. It is able to distinguish between IL-2 secreting T cell and IFN–g-secreting T cell and can be used as a marker for LCMV-specific cells. However, it is important to note that a positive response to NRP2 does not always mean that the virus is infected.

Detection of circulating levels in HRS:NRP2 complexes

NRP2-associated disease is diagnosed by the detection of NRP2 compounds in the blood. This complex binds to NRP2's 3-b promoter. The HRS:NRP2 complex can be measured in the circulating blood to determine its levels. This method is useful in diagnosing NRP2-associated and NRP2-associated malignancies.

Detection of circulating levels of NRP2 is essential for early diagnosis of cancer. The NRP2 protein plays a role in tumor metastasis. Therefore, HRS:NRP2 complexes may help to predict the prognosis for cancer patients. This test can help patients with OS determine their risk for tumor metastasis.

In addition to being a vital marker for early cancer diagnosis, HRS/NRP2 can also help detect cancer cells metastases. The HRS:NRP2 human complex is a coreceptor to VEGF Signaling. This pathway regulates activity of the integrin a6b1. It also promotes the development of mammospheres. The interaction between NRP2 integrin and endothelial cellular cells is done by the A6b1 Integrin.

The HRS:NRP2 polypeptide has two major subtypes: Sema3F-p65 and HRS-p65. The human NRP2 protein molecule is distinguished by its asymmetrically helix-shaped rings. These proteins are monomers because they are very similar in structure and function. These proteins can also be linked to other cellular processes.

The NRP2 diagnostic system includes an indicator molecule, cells expressing neuropilin 2, and cells expressing it. You can choose from Table N2, N3, Table h2, Table h2, or h2. The resulting signal from this assay can indicate if the NRP2 levels have risen. It can also indicate whether the NRP2 activity has changed in size.

Positive results were obtained from a study examining the effect of NRP2 inhibition on angiogenesis. Knockdown NRP2 in osteosarcoma cellular cells inhibited growth, and inhibited recruitment HUVEC cells. Knockdowns to the NRP2 signaling receptor resulted in osteosarcoma cells shrinking and Wnt signaling being inhibited.

Human antibodies were used for the detection of aNRP2 complicatedes. These antibodies were incubated with cells at the indicated concentrations. The cells were then incubated with the indicated aNRP2 inhibitors. After this treatment the patients responded positively with the HRS-NRP2 combinations. This test has been validated for a wide array of conditions.

The predicted miR146a sequences for human NRP2 3’UTR are included in the human NRP2 3. Overexpression miR146a interfered with miR146a recognition. The NRP2-miR146a complex showed an inverse correlation between NRP2 & miR-146a. The NRP2-miR146a correlation was particularly strong in the circulating NRP2.