SYNGAP1 Antibodies

AND SYNGAP1 ELISA kits, SYNGAP1 Proteins

Many biological assays use antibodies to detect SYNGAP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SYNGAP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SYNGAP1 antibodies...

We validate the specificity of these antibodies to SYNGAP1 by testing them on tissues known to express SYNGAP1 positively and negatively. Browse below to find the SYNGAP1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SYNGAP1 Infographic by Boster Bio

All SYNGAP1 Products

Product

Figures

Specificity

Applications

Price

Anti-SynGAP Rabbit Monoclonal Antibody

1 Q&As

Human, Mouse, Rat

Flow Cytometry, IF, ICC, WB

$370
Cat # M04862
100 μl

Anti-SYGP1 SYNGAP1 Antibody

Human, Mouse, Rat

ELISA, WB

$380
Cat # A04862
100ul

Anti-SYNGAP1 Antibody Picoband™

Human, Mouse, Rat

ELISA, Flow Cytometry, WB

$370
Cat # A04862-1
100 µg/vial

SYNGAP1 Overview

Facts about Ras/Rap GTPase-activating protein SynGAP.

SYNGAP1 3D structure. Source: alphafold

Ras/Rap GTPase-activating protein SynGAP (SYNGAP1)

Inhibitory regulator of this Ras-cAMP pathway. Member of the NMDAR signaling complex in excitatory synapses, it may play a role in NMDAR-dependent control of AMPAR potentiation, AMPAR membrane trafficking and synaptic plasticity.

Regulates AMPAR- mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap.

Gene Information

Human
Gene Name:	SYNGAP1
Uniprot:	Q96PV0
Entrez:	8831

Family

Belongs to:

No superfamily

Alternative Names

DKFZp761G1421; KIAA1938135kDa; MRD5; synaptic Ras GTPase activating protein 1 homolog (rat); synaptic Ras GTPase activating protein 1; Synaptic Ras-GAP 1

Molecular Weight

Mass (kDA):
148.284 kDA

Genomic Context


Human

Location:	6p21.32
Sequence:	6; NC_000006.12 (33420065..33453689)

Diseases

Autistic Disorder
Schizophrenia
Autism Spectrum Disorders
Epilepsy
Memory Disorders
Nervousness
Learning Disorders
Brain Ischemia
Epilepsy, Generalized
Ischemia
Haploinsufficiency

Depressive Disorder
Memory Impairment
Cerebral Ischemia
Mutation, Out-of-frame
Brain Injury, Chronic
Hypoxia

Pathways

Localization
Synaptic Transmission
Cognition
Synapse Maturation
Methylation
Secretory Pathway
Axon Extension
Sensitization
Gene Silencing

Regulation Of Axon Extension
Segmentation
Innervation

PTMs

Phosphorylation
Dephosphorylation

Reduction
Cleavage

Methylation

Research Areas

Cognition and Behavior
Neuroscience
Vision

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SYNGAP1

References

PMID: 15312654 by Krapivinsky G., et al. SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation.

PMID: 19196676 by Hamdan F.F., et al. Mutations in SYNGAP1 in autosomal nonsyndromic mental retardation.