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- Table of Contents
Facts about Ras/Rap GTPase-activating protein SynGAP.
Regulates AMPAR- mediated miniature excitatory postsynaptic currents. Exhibits dual GTPase-activating specificity for Ras and Rap.
Human | |
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Gene Name: | SYNGAP1 |
Uniprot: | Q96PV0 |
Entrez: | 8831 |
Belongs to: |
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No superfamily |
DKFZp761G1421; KIAA1938135kDa; MRD5; synaptic Ras GTPase activating protein 1 homolog (rat); synaptic Ras GTPase activating protein 1; Synaptic Ras-GAP 1
Mass (kDA):
148.284 kDA
Human | |
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Location: | 6p21.32 |
Sequence: | 6; NC_000006.12 (33420065..33453689) |
PMID: 15312654 by Krapivinsky G., et al. SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation.
PMID: 19196676 by Hamdan F.F., et al. Mutations in SYNGAP1 in autosomal nonsyndromic mental retardation.