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NUDT1 Antibodies
AND NUDT1 ELISA kits, NUDT1 Proteins
Many biological assays use antibodies to detect NUDT1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NUDT1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NUDT1 antibodies...
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NUDT1 Infographic by Boster Bio
All NUDT1 Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IP, IF, IHC, ICC, WB
$370
Cat # M04258
100 μl/vial
Cat # M04258
100 μl/vial
NUDT1 Overview
Facts about 7,8-dihydro-8-oxoguanine triphosphatase.
7,8-dihydro-8-oxoguanine triphosphatase (NUDT1)
Antimutagenic (PubMed:8226881, PubMed:7713500, PubMed:10608900).
Plays a redundant function in sanitizing oxidized nucleotide pools, such as 8-oxo-dGTP pools (PubMed:28679043).Acts as a sanitizing enzyme for oxidized nucleotide pools, thus suppressing cell dysfunction and death induced by oxidative stress (PubMed:12857738, PubMed:24695224, PubMed:24695225). Hydrolyzes 8- oxo-dGTP, 8-oxo-dATP and 2-OH-dATP, thus preventing misincorporation of oxidized purine nucleoside triphosphates to DNA and preventing A:T to C:G and G:C to T:A transversions (PubMed:8226881, PubMed:10373420, PubMed:10608900, PubMed:11756418, PubMed:12857738, PubMed:16607562, PubMed:24695224, PubMed:24695225, PubMed:26999531, PubMed:28035004).
Gene Information
| Human | |
|---|---|
| Gene Name: | NUDT1 |
| Uniprot: | P36639 |
| Entrez: | 4521 |
Family
| Belongs to: |
|---|
| Nudix hydrolase family |
Alternative Names
8-oxo-7,8-dihydrodeoxyguanosine triphosphatase; EC 3.6.1.-; MTH1Nucleoside diphosphate-linked moiety X motif 1; mutT human homolog 1,8-oxo-dGTPase; nucleoside diphosphate-linked moiety X-type motif 17,8-dihydro-8-oxoguanine triphosphatase; nudix (nucleoside diphosphate linked moiety X)-type motif 1,8-oxo-7,8-dihydroguanosine triphosphatase; Nudix motif 1
Molecular Weight
Mass (kDA):
22.52 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7p22.3 |
| Sequence: | 7; NC_000007.14 (2242222..2251145) |
Tissue Specificity
Widely expressed with highest expression in thymus, testis, embryo and proliferating blood lymphocytes.
Subcellular Localizations
[Isoform p18]: Cytoplasm, cytosol. Mitochondrion matrix. Nucleus. Mostly present in cytosol (PubMed:7782328). A minor proportion is mitochondrial (PubMed:7782328). A very small amount of the protein is associated with nuclei (PubMed:7782328). Variant Met-124 has decreased efficiency in translocation to mitochondria (PubMed:16607562).; [Isoform p26]: Mitochondrion matrix.
Diseases
- Malignant Neoplasms
- Lung Neoplasms
- Neoplasms
- Malignant Neoplasm Of Lung
- Colorectal Cancer
- Adenoma
- Adenocarcinoma
- Adenomatous Polyposis Coli
- Carcinogenesis
- Hereditary Nonpolyposis Colorectal Cancer
- Polyposis
- Cholangiocarcinoma
Interacting Proteins
- ACY1
Pathways
- Dna Repair
- Aging
- Mismatch Repair
- Dna Replication
- Excretion
- Dna Protection
- Cell Proliferation
- Cell Cycle Arrest
- Cell Cycle
PTMs
- Cleavage
Research Areas
- Base Excision Repair
- Cancer
- Chromatin Research
- DNA Repair
- Modulation of DNA Pools
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NUDT1
bosterbio.com/bosterbio-gene-info-cards/NUDT1
References
PMID: 8226881 by Sakumi K., et al. Cloning and expression of cDNA for a human enzyme that hydrolyzes 8- oxo-dGTP, a mutagenic substrate for DNA synthesis.
PMID: 7713500 by Furuichi M., et al. Genomic structure and chromosome location of the human mutT homologue gene MTH1 encoding 8-oxo-dGTPase for prevention of A:T to C:G transversion.