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- Table of Contents
Facts about C-1-tetrahydrofolate synthase, cytoplasmic.
Human | |
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Gene Name: | MTHFD1 |
Uniprot: | P11586 |
Entrez: | 4522 |
Belongs to: |
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No superfamily |
C1-THF synthase; EC 6.3.4.3; methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthetase5,10-methylenetetrahydrofolate dehydrogenase, 5,10-methylenetetrahydrofolatecyclohydrolase, 10-formyltetrahydrofolate synthetase; methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1; MTHFCC-1-tetrahydrofolate synthase, cytoplasmic; MTHFDcytoplasmic C-1-tetrahydrofolate synthase
Mass (kDA):
101.559 kDA
Human | |
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Location: | 14q23.3 |
Sequence: | 14; NC_000014.9 (64388353..64460025) |
Ubiquitous.
Cytoplasm.
PMID: 3053686 by Hum D.W., et al. Primary structure of a human trifunctional enzyme. Isolation of a cDNA encoding methylenetetrahydrofolate dehydrogenase- methenyltetrahydrofolate cyclohydrolase-formyltetrahydrofolate synthetase.
PMID: 9519408 by Allaire M., et al. The 3-D structure of a folate-dependent dehydrogenase/cyclohydrolase bifunctional enzyme at 1.5-A resolution.