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- Table of Contents
Facts about N-terminal Xaa-Pro-Lys N-methyltransferase 1.
Some of the substrates could be primed by METTL11B-mediated monomethylation (PubMed:24090352). Catalyzes the trimethylation of this N-terminal Gly in CENPA (after elimination of Met-1).
Human | |
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Gene Name: | NTMT1 |
Uniprot: | Q9BV86 |
Entrez: | 28989 |
Belongs to: |
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methyltransferase superfamily |
AD-003; alpha N-terminal protein methyltransferase 1A; C9orf32; chromosome 9 open reading frame 32; EC 2.1.1.-; methyltransferase like 11A; Methyltransferase-like protein 11A; METTL11A; NRMT; N-terminal RCC1 methyltransferase; NTM1A; NTMT1; X-Pro-Lys N-terminal protein methyltransferase 1A
Mass (kDA):
25.387 kDA
Human | |
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Location: | 9q34.11 |
Sequence: | 9; NC_000009.12 (129608884..129636742) |
Nucleus. Predominantly nuclear (PubMed:24090352).
PMID: 20481588 by Webb K.J., et al. Identification of protein N-terminal methyltransferases in yeast and humans.
PMID: 20668449 by Tooley C.E., et al. NRMT is an alpha-N-methyltransferase that methylates RCC1 and retinoblastoma protein.