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- Table of Contents
Facts about COMM domain-containing protein 5.
Negatively regulates cell cycle G2/M phase transition likely by transactivating p21/CDKN1A through the p53/TP53-independent signaling pathway. Involved in kidney proximal tubule morphogenesis (By similarity).
Human | |
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Gene Name: | COMMD5 |
Uniprot: | Q9GZQ3 |
Entrez: | 28991 |
Belongs to: |
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No superfamily |
COMM domain-containing protein 5
Mass (kDA):
24.67 kDA
Human | |
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Location: | 8q24.3 |
Sequence: | 8; NC_000008.11 (144837978..144853556, complement) |
Highly expressed in heart, stomach, jejunum, kidney, liver, and adrenal gland. Expression was generally higher in adult organs than in fetal tissues, particularly in heart, kidney, and liver.
Cytoplasm. Nucleus.
PMID: 10918053 by Solban N., et al. HCaRG, a novel calcium-regulated gene coding for a nuclear protein, is potentially involved in the regulation of cell proliferation.
PMID: 15799966 by Burstein E., et al. COMMD proteins, a novel family of structural and functional homologs of MURR1.