NSMCE4A Antibodies

AND NSMCE4A ELISA kits, NSMCE4A Proteins

Many biological assays use antibodies to detect NSMCE4A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NSMCE4A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NSMCE4A antibodies...

We validate the specificity of these antibodies to NSMCE4A by testing them on tissues known to express NSMCE4A positively and negatively. Browse below to find the NSMCE4A antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NSMCE4A Infographic by Boster Bio

All NSMCE4A Products

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Product

Figures

Specificity

Applications

Price

NSMCE4A (NM_017615) Human Over-expression Lysate

Human

$628
Cat # LS054780
100 µg

Anti-NSMCE4A Antibody Picoband®

Human, Mouse, Rat

ELISA, Flow Cytometry, IF, ICC, WB

$370
Cat # A14289-1
100 µg/vial

NSMCE4A Overview

Facts about Non-structural maintenance of chromosomes element 4 homolog A.

NSMCE4A 3D structure. Source: alphafold

Non-structural maintenance of chromosomes element 4 homolog A (NSMCE4A)

Component of the SMC5-SMC6 complex, a complex involved in DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks.

The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complicated (telosome) components which is suggested to lead to shelterin complicated disassembly in ALT- associated PML bodies (APBs). Is involved in positive regulation of response to DNA damage stimulus.

Gene Information

Human
Gene Name:	NSMCE4A
Uniprot:	Q9NXX6
Entrez:	54780

Family

Belongs to:

NSE4 family

Alternative Names

FLJ20003; non-SMC element 4 homolog A (S. cerevisiae); PP4762

Molecular Weight

Mass (kDA):
44.301 kDA

Genomic Context


Human

Location:	10q26.13
Sequence:	10; NC_000010.11 (121957088..121975228, complement)

Subcellular Localizations

Nucleus. Chromosome, telomere.

Interacting Proteins

NSMCE3

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NSMCE4A

References

PMID: 18086888 by Taylor E.M., et al. Identification of the proteins, including MAGEG1, that make up the human SMC5-6 protein complex.

PMID: 27427983 by van der Crabben S.N., et al. Destabilized SMC5/6 complex leads to chromosome breakage syndrome with severe lung disease.