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- Table of Contents
Facts about E3 SUMO-protein ligase NSE2.
The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components. Acts as an E3 ligase mediating SUMO attachment to various proteins such as SMC6L1 and TRAX, the shelterin complex subunits TERF1, TERF2, TINF2 and TERF2IP, and maybe the cohesin components RAD21 and STAG2.
Mouse | |
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Gene Name: | Nsmce2 |
Uniprot: | Q91VT1 |
Entrez: | 68501 |
Belongs to: |
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NSE2 family |
C8orf36; E3 SUMO-protein ligase NSE2; EC 6.3.2; EC 6.3.2.-; FLJ32440; hMMS21; methyl methanesulfonate sensitivity gene 21; MMS21 homolog; MMS21chromosome 8 open reading frame 36; non-SMC element 2 homolog (MMS21, S. cerevisiae); Non-SMC element 2 homolog; non-SMC element 2, MMS21 homolog (S. cerevisiae); Non-structural maintenance of chromosomes element 2 homolog; NSE2
Mass (kDA):
28.231 kDA
Mouse | |
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Location: | 15|15 D1 |
Sequence: | 15; |
PMID: 16141072 by Carninci P., et al. The transcriptional landscape of the mammalian genome.