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- Table of Contents
Facts about Histone-lysine N-methyltransferase NSD3.
H3'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while'Lys-27' is a mark for transcriptional repression. .
Human | |
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Gene Name: | NSD3 |
Uniprot: | Q9BZ95 |
Entrez: | 54904 |
Belongs to: |
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class V-like SAM-binding methyltransferase superfamily |
Histone-lysine N-methyltransferase NSD3
Mass (kDA):
161.613 kDA
Human | |
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Location: | 8p11.23 |
Sequence: | 8; NC_000008.11 (38269704..38382272, complement) |
Highly expressed in brain, heart and skeletal muscle. Expressed at lower level in liver and lung.
Nucleus. Chromosome.
PMID: 11549311 by Stec I., et al. WHSC1L1, on human chromosome 8p11.2, closely resembles WHSC1 and maps to a duplicated region shared with 4p16.3.
PMID: 11374904 by Angrand P.-O., et al. NSD3, a new SET domain-containing gene, maps to 8p12 and is amplified in human breast cancer cell lines.