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Glucocorticoid receptor Antibodies
AND NR3C1 ELISA kits, Glucocorticoid receptor Proteins
Many biological assays use antibodies to detect Glucocorticoid receptor, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Glucocorticoid receptor in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Glucocorticoid receptor antibodies...
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NR3C1 Infographic by Boster Bio
All NR3C1 Products
Product
Figures
Specificity
Applications
Price
Human
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # PB9232
100 μg/vial
Cat # PB9232
100 μg/vial
Anti-Glucocorticoid Receptor/NR3C1 Antibody Picoband®
2 Citations 2 Q&As
Human, Mouse, Rat
IHC, WB
$370
Cat # PB9342
100 μg/vial
Cat # PB9342
100 μg/vial
Human, Mouse, Rat
Flow Cytometry, WB
$370
Cat # M00503
100 μl
Cat # M00503
100 μl
Human, Mouse, Rat
ELISA
$480
Cat # EKC1248
1 kit, containing one 96-well plate and all necessary reagents
Cat # EKC1248
1 kit, containing one 96-well plate and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC1987
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC1987
1 kit, containing two 96-well plates and all necessary reagents
Human, Mouse, Rat
ELISA
$540
Cat # EKC2036
1 kit, containing two 96-well plates and all necessary reagents
Cat # EKC2036
1 kit, containing two 96-well plates and all necessary reagents
Human
$628
Cat # LS002908
100 µg
Cat # LS002908
100 µg
NR3C1 Overview
Facts about Glucocorticoid receptor.
Glucocorticoid receptor (NR3C1)
Receptor for glucocorticoids (GC) (PubMed:27120390). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE), both for nuclear and mitochondrial DNA, and as a modulator of other transcription factors.
Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Involved in chromatin remodeling (PubMed:9590696).
Gene Information
| Human | |
|---|---|
| Gene Name: | NR3C1 |
| Uniprot: | P04150 |
| Entrez: | 2908 |
Family
| Belongs to: |
|---|
| nuclear hormone receptor family |
Alternative Names
GCR; glucocorticoid receptor; GR; GRGCCR; GRLNuclear receptor subfamily 3 group C member 1; NR3C1; nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor); nuclear receptor subfamily 3, group C, member 1
Molecular Weight
Mass (kDA):
85.659 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 5q31.3 |
| Sequence: | 5; NC_000005.10 (143277931..143435512, complement) |
Tissue Specificity
Widely expressed including bone, stomach, lung, liver, colon, breast, ovary, pancreas and kidney (PubMed:25847991). In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart (PubMed:10902803). Isoform Beta: Widely expressed including brain, bone marrow, thymus, spleen, liver, kidney, pancreas, lung, fat, skeletal muscle, heart, placenta and blood leukocytes (PubMed:7769088, PubMed:8621628). Isoform Alpha-2: Expressed at low level.
Subcellular Localizations
[Isoform Alpha]: Cytoplasm. Nucleus. Mitochondrion. Cytoplasm, cytoskeleton, spindle. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. After ligand activation, translocates from the cytoplasm to the nucleus. In the presence of NR1D1 shows a time-dependent subcellular localization, localizing to the cytoplasm at ZT8 and to the nucleus at ZT20 (By similarity). Lacks this diurnal pattern of localization in the absence of NR1D1, localizing to both nucleus and the cytoplasm at ZT8 and ZT20 (By similarity).; [Isoform Beta]: Nucleus. Cytoplasm. Expressed predominantly in the nucleu
Diseases
- Depressive Disorder
- Obesity
- Neoplasms
- Malignant Neoplasms
- Asthma
- Stress, Psychological
- Hypertensive Disease
- Leukemia
- Mental Disorders
- Acute Lymphocytic Leukemia
- Carcinoma
- Inflammation
- Dysequilibrium Syndrome
Interacting Proteins
- AKT1
- Asxl1
- CAV1
- CD4
- EGFR
- HNF4A
- HSP90AA1
- KIAA0408
- LCK
- Mvp
Pathways
- Methylation
- Dna Methylation
- Secretion
- Pathogenesis
- Response To Stress
- Transport
- Hypersensitivity
- Translation
- Cell Proliferation
- Cell Cycle
- Cell Adhesion
- Lymphocyte Proliferation
- Lactation
PTMs
- Methylation
- Phosphorylation
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NR3C1
bosterbio.com/bosterbio-gene-info-cards/NR3C1
References
PMID: 2867473 by Hollenberg S.M., et al. Primary structure and expression of a functional human glucocorticoid receptor cDNA.
PMID: 1707881 by Encio I.J., et al. The genomic structure of the human glucocorticoid receptor.
4 Publications of Boster Glucocorticoid receptor Antibodies & ELISA Kits
- PubMed ID: 10.4158/EP-2019-0475, A Novel Glucocorticoid Receptor Mutation in Primary Generalized Glucocorticoid R...
- PubMed ID: 10.1007/s10072-011-0597-1, Expression of locus coeruleus mineralocorticoid receptor and glucocorticoid rece...
- PubMed ID: -, Lifen Ma,Xiaozhen Tan,Jiaqi Li,Yang Long,Zhen Xiao,Ji De,Yan Ren,Haoming Tian,T....
- PubMed ID: 28754919, Sharma S, Maras JS, Das S, Hussain S, Mishra AK, Shasthry SM, Sharma CB, Weiss E...
*More publications can be found for each product on its corresponding product page