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- Table of Contents
Facts about Rho GTPase-activating protein 35.
Involved in cell differentiation and cell adhesion and migration, plays an essential role in retinal tissue morphogenesis, neural tube combination, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras into the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity).
Human | |
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Gene Name: | ARHGAP35 |
Uniprot: | Q9NRY4 |
Entrez: | 2909 |
Belongs to: |
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No superfamily |
glucocorticoid receptor DNA binding factor 1; glucocorticoid receptor DNA-binding factor 1; glucocorticoid receptor repression factor 1; GRF1; GRF-1; GRLF1; KIAA1722; MGC10745; P190A; P190-A; p190ARhoGAP; p190RhoGAP; rho GAP p190A; Rho GTPase activating protein 35; rho GTPase-activating protein 35
Mass (kDA):
170.514 kDA
Human | |
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Location: | 19q13.32 |
Sequence: | 19; NC_000019.10 (46860997..47005077) |
Detected in neutrophils (at protein level).
Cytoplasm, cytoskeleton, cilium basal body. Cytoplasm. Nucleus. Cell membrane. In response to integrins and SDC4 and upon phosphorylation by PKC, relocalizes from the cytoplasm to regions of plasma membrane ruffling where it colocalizes with polymerized actin.
PMID: 11054565 by Tikoo A., et al. p190-A, a human tumor suppressor gene, maps to the chromosomal region 19q13.3 that is reportedly deleted in some gliomas.
PMID: 1894621 by LeClerc S., et al. Molecular cloning and characterization of a factor that binds the human glucocorticoid receptor gene and represses its expression.