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- Table of Contents
Facts about Nuclear receptor subfamily 2 group C member 1.
Primarily repressor of a wide selection of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences.
Human | |
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Gene Name: | NR2C1 |
Uniprot: | P13056 |
Entrez: | 7181 |
Belongs to: |
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nuclear hormone receptor family |
NR2C1; nuclear receptor subfamily 2 group C member 1; nuclear receptor subfamily 2, group C isoform; nuclear receptor subfamily 2, group C, member 1; Orphan nuclear receptor TR2; Testicular receptor 2; TR2 nuclear hormone receptor; TR2; TR2-11
Mass (kDA):
67.315 kDA
Human | |
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Location: | 12q22 |
Sequence: | 12; NC_000012.12 (95020229..95073618, complement) |
Nucleus. Nucleus, PML body. Recruited by HDAC3, after all-trans retinoic acid stimulated MAPK1-mediated Thr-223 phosphorylation, to PML bodies for subsequent sumoylation.
PMID: 3421977 by Chang C., et al. Identification of a new member of the steroid receptor super-family by cloning and sequence analysis.
PMID: 2597158 by Chang C., et al. Molecular cloning of new human TR2 receptors: a class of steroid receptor with multiple ligand-binding domains.