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NR1D1 Antibodies
AND NR1D1 ELISA kits, NR1D1 Proteins
Many biological assays use antibodies to detect NR1D1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NR1D1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NR1D1 antibodies...
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NR1D1 Infographic by Boster Bio
All NR1D1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # M01077-1
100 μl/vial
Cat # M01077-1
100 μl/vial
NR1D1 Overview
Facts about Nuclear receptor subfamily 1 group D member 1.
Nuclear receptor subfamily 1 group D member 1 (NR1D1)
Transcriptional repressor which coordinates circadian rhythm and metabolic pathways in a heme-dependent manner. Integral component of the complex transcription machinery that modulates circadian rhythmicity and forms a critical negative limb of the circadian clock by directly repressing the expression of core clock parts ARTNL/BMAL1, CLOCK and CRY1.
Also regulates genes involved in metabolic functions, including lipid and bile acid metabolism, adipogenesis, gluconeogenesis and the macrophage inflammatory response. Acts as a receptor for heme which stimulates its interaction with the NCOR1/HDAC3 corepressor complex, enhancing transcriptional repression.
Gene Information
| Human | |
|---|---|
| Gene Name: | NR1D1 |
| Uniprot: | P20393 |
| Entrez: | 9572 |
Family
| Belongs to: |
|---|
| nuclear hormone receptor family |
Alternative Names
Ear-1; EAR1nuclear receptor subfamily 1 group D member 1; HREV; NR1D1; nuclear receptor subfamily 1, group D, member 1; Reverb A alpha; Rev-erb A alpha; Rev-ErbAalpha; Rev-erbA-alpha; THRA1; THRAL; THRALrev-erbA-alpha; V-erbA-related protein 1
Molecular Weight
Mass (kDA):
66.805 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.1 |
| Sequence: | 17; NC_000017.11 (40092793..40100589, complement) |
Tissue Specificity
Widely expressed. Expressed at high levels in the liver, adipose tissue, skeletal muscle and brain. Also expressed in endothelial cells (ECs), vascular smooth muscle cells (VSMCs) and macrophages. Expression oscillates diurnally in the suprachiasmatic nucleus (SCN) of the hypothalamus as well as in peripheral tissues. Expression increases during the differentiation of pre-adipocytes into mature adipocytes. Expressed at high levels in some squamous carcinoma cell lines.
Subcellular Localizations
Nucleus. Cytoplasm. Cell projection, dendrite. Cell projection, dendritic spine. Localizes to the cytoplasm, dendrites and dendritic spine in the presence of OPHN1. Localizes predominantly to the nucleus at ZT8 whereas it is cytoplasmic at ZT20. Phosphorylation by CSNK1E enhances its cytoplasmic localization.
Diseases
- Neoplasms
- Obesity
- Malignant Neoplasms
- Bipolar Disorder
- Inflammation
- Diabetes Mellitus
- Depressive Disorder
- Liver Carcinoma
- Malignant Neoplasm Of Breast
- Metabolic Diseases
- Atherosclerosis
- Mammary Neoplasms
Interacting Proteins
- APOA4
- HUWE1
- NCOR1
- Per2
Pathways
- Circadian Rhythm
- Secretion
- Cell Cycle
- Cell Growth
- Pathogenesis
- Rna Interference
- Glucose Homeostasis
- Cell Proliferation
- Energy Homeostasis
- Regulation Of Gene Expression
- Bioluminescence
- Angiogenesis
- Cell Cycle Arrest
PTMs
- Phosphorylation
- Acetylation
- Reduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NR1D1
bosterbio.com/bosterbio-gene-info-cards/NR1D1
References
PMID: 2539258 by Miyajima N., et al. Two erbA homologs encoding proteins with different T3 binding capacities are transcribed from opposite DNA strands of the same genetic locus.
PMID: 1971514 by Lazar M.A., et al. Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone.