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- Table of Contents
Facts about Growth/differentiation factor 3.
Regulates adipose-tissue homeostasis and energy balance under nutrient overload in part by signaling through the receptor complex based on ACVR1C and TDGF1/Cripto (PubMed:21805089). .
Human | |
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Gene Name: | GDF3 |
Uniprot: | Q9NR23 |
Entrez: | 9573 |
Belongs to: |
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TGF-beta family |
GDF3; GDF-3; growth differentiation factor 3; growth/differentiation factor 3; KFS3; MCOP7; MCOPCB6; Vgr-2
Mass (kDA):
41.387 kDA
Human | |
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Location: | 12p13.31 |
Sequence: | 12; NC_000012.12 (7689784..7695775, complement) |
Secreted. Cytoplasm. Mainly accumulated in the cytoplasm.
PMID: 21805089 by Li Q., et al. The conditioned medium from a stable human GDF3-expressing CHO cell line, induces the differentiation of PC12 cells.
PMID: 19864492 by Ye M., et al. Mutation of the bone morphogenetic protein GDF3 causes ocular and skeletal anomalies.