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NPRL2 Antibodies
AND NPRL2 ELISA kits, NPRL2 Proteins
Many biological assays use antibodies to detect NPRL2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NPRL2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NPRL2 antibodies...
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NPRL2 Infographic by Boster Bio
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NPRL2 Overview
Facts about GATOR complex protein NPRL2.
GATOR complex protein NPRL2 (NPRL2)
As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling.
The GATOR1 complex is negatively regulated by GATOR2 the other GATOR subcomplex in this amino acid-sensing branch of the TORC1 pathway. .
Gene Information
| Human | |
|---|---|
| Gene Name: | NPRL2 |
| Uniprot: | Q8WTW4 |
| Entrez: | 10641 |
Family
| Belongs to: |
|---|
| NPR2 family |
Alternative Names
G21 protein; Gene 21 protein; homologous to yeast nitrogen permease (candidate tumor suppressor); nitrogen permease regulator 2-like protein; nitrogen permease regulator-like 2 (S. cerevisiae); NPR2; NPR2L2810446G01Rik; NPRL2; Tumor suppressor candidate 4NPR2-like protein; TUSC4
Molecular Weight
Mass (kDA):
43.658 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 3p21.31 |
| Sequence: | 3; NC_000003.12 (50347330..50350821, complement) |
Tissue Specificity
Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in the frontal lobe cortex as well as in the temporal, parietal, and occipital lobes (PubMed:27173016, PubMed:26505888). Expressed in most lung cancer cell lines tested.
Subcellular Localizations
Lysosome membrane. Localization to lysosomes is amino acid-independent.
Diseases
- Neoplasms
- Malignant Neoplasms
- Malignant Neoplasm Of Lung
- Carcinoma
- Lung Neoplasms
- Non-small Cell Lung Carcinoma
- Neoplasm Metastasis
- Malignant Squamous Cell Neoplasm
- Malignant Neoplasm Of Breast
- Kidney Neoplasm
- Carcinogenesis
- Severe Combined Immunodeficiency
- Renal Cell Carcinoma
Interacting Proteins
- NPRL3
Pathways
- Cell Cycle
- Cell Proliferation
- Methylation
- Cell Growth
- Cell Cycle Checkpoint
- Induction Of Apoptosis
- Localization
- Mismatch Repair
- Cell Killing
- Dna Repair
- Sensitization
PTMs
- Methylation
- Phosphorylation
- Demethylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NPRL2
bosterbio.com/bosterbio-gene-info-cards/NPRL2
References
PMID: 11085536 by Lerman M.I., et al. The 630-kb lung cancer homozygous deletion region on human chromosome 3p21.3: identification and evaluation of the resident candidate tumor suppressor genes.
PMID: 11980673 by Ji L., et al. Expression of several genes in the human chromosome 3p21.3 homozygous deletion region by an adenovirus vector results in tumor suppressor activities in vitro and in vivo.