NPLOC4 Antibodies

AND NPLOC4 ELISA kits, NPLOC4 Proteins

Many biological assays use antibodies to detect NPLOC4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NPLOC4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NPLOC4 antibodies...

We validate the specificity of these antibodies to NPLOC4 by testing them on tissues known to express NPLOC4 positively and negatively. Browse below to find the NPLOC4 antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NPLOC4 Infographic by Boster Bio

All NPLOC4 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-NPLOC4 Antibody

Human, Mouse, Rat

IF, ICC, WB

$405
Cat # A08476
100ul

NPL4 (NPLOC4) (NM_017921) Human Recombinant Protein

$1062
Cat # PROTQ8TAT6
20 µg

Anti-NPL4/NPLOC4 Antibody Picoband®

Human, Mouse, Rat

ELISA, IF, ICC, WB

$370
Cat # A08476-1
100 μg/vial

NPL4 (NPLOC4) (NM_017921) Human Over-expression Lysate

Human

$628
Cat # LS055666
100 µg

NPLOC4 Overview

Facts about Nuclear protein localization protein 4 homolog.

NPLOC4 3D structure. Source: alphafold

Nuclear protein localization protein 4 homolog (NPLOC4)

The ternary complex containing UFD1, VCP and NPLOC4 binds ubiquitinated proteins and is essential for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. The NPLOC4-UFD1-VCP complex regulates spindle disassembly at the end of mitosis and is necessary for the formation of a closed nuclear envelope (By similarity).

Acts as a negative regulator of type I interferon production through the complex formed with VCP and UFD1, which contrasts to DDX58/RIG-I and recruits RNF125 to promote ubiquitination and degradation of DDX58/RIG-I (PubMed:26471729). .

Gene Information

Human
Gene Name:	NPLOC4
Uniprot:	Q8TAT6
Entrez:	55666

Family

Belongs to:

NPL4 family

Alternative Names

FLJ20657; FLJ23742; KIAA1499nuclear protein localization protein 4 homolog; NPL4Protein NPL4; nuclear protein localization 4 homolog (S. cerevisiae)

Molecular Weight

Mass (kDA):
68.12 kDA

Genomic Context


Human

Location:	17q25.3
Sequence:	17; NC_000017.11 (81556885..81637148, complement)

Tissue Specificity

Expressed at highest levels in brain, heart, skeletal muscle, kidney and fetal liver.

Subcellular Localizations

Cytoplasm, cytosol. Endoplasmic reticulum. Nucleus. Associated with the endoplasmic reticulum and nuclear.

Diseases

Aortic Aneurysm, Abdominal
Cystic Fibrosis
Exposure To Ionizing Radiation
Osteitis Deformans
Inclusion Body Myositis (disorder)
Frontotemporal Dementia
Ataxia
Dementia
Genomic Instability
Malignant Paraganglionic Neoplasm
Cholera
Myopathy

Fibrosis
Cytomegalovirus Infections
Neoplasms
Dislocations
Hiv Infections
Machado-joseph Disease
Ataxia, Spinocerebellar

Interacting Proteins

UFD1

Pathways

Cell Death
Rna Interference
Induction Of Apoptosis
Mitosis
Proteolysis
Dna Repair
Metaphase
Endocytosis
Membrane Fusion
Chromosome Segregation

Conjugation
Anaphase
Cell Cycle
Exit From Mitosis
Autophagy

PTMs

Ubiquitination

Phosphorylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NPLOC4

References

PMID: 11574150 by Botta A., et al. Cloning and characterization of the gene encoding human NPL4, a protein interacting with the ubiquitin fusion-degradation protein (UFD1L).

PMID: 24160817 by Glinka T., et al. Signal-peptide-mediated translocation is regulated by a p97-AIRAPL complex.