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- Table of Contents
Facts about Neuropeptide FF receptor 2.
This receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. .
Human | |
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Gene Name: | NPFFR2 |
Uniprot: | Q9Y5X5 |
Entrez: | 10886 |
Belongs to: |
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G-protein coupled receptor 1 family |
GPR74; GPR74G protein-coupled receptor 74; G-protein coupled receptor 74; neuropeptide FF 2; neuropeptide FF receptor 2; Neuropeptide G-protein coupled receptor; NPFF2; NPFF2G-protein coupled receptor HLWAR77; NPFFR2; NPGPR; NPGPRHLWAR77
Mass (kDA):
60.27 kDA
Human | |
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Location: | 4q13.3 |
Sequence: | 4; NC_000004.12 (72031804..72148201) |
Isoform 1 is abundant in placenta. Relatively highly expressed in thymus, testis, and small intestine. Expressed at low levels in several tissues including spleen, prostate, brain, heart, ovary, colon, kidney, lung, liver and pancreas and not expressed in skeletal muscle and leukocytes. Isoform 2 expression is highest in placenta (but at relatively low level compared to isoform 1). Very low level of expression in numerous tissues including adipose tissue and many brain regions. Isoform 3 is expressed in brain and heart and, at lower levels, in kidney, liver, lung and pancreas.
Cell membrane; Multi-pass membrane protein.
PMID: 10079187 by Cikos S., et al. Sequence and tissue distribution of a novel G-protein-coupled receptor expressed prominently in human placenta.
PMID: 10851242 by Elshourbagy N.A., et al. Receptor for the pain modulatory neuropeptides FF and AF is an orphan G protein-coupled receptor.