NPAS1 Antibodies

AND NPAS1 ELISA kits, NPAS1 Proteins

Many biological assays use antibodies to detect NPAS1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NPAS1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NPAS1 antibodies...

We validate the specificity of these antibodies to NPAS1 by testing them on tissues known to express NPAS1 positively and negatively. Browse below to find the NPAS1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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NPAS1 Infographic by Boster Bio

All NPAS1 Products

Product

Figures

Specificity

Applications

Price

Anti-NPAS1 Antibody

Human, Mouse, Rat

$405
Cat # A10933
100ul

Anti-PASD5 (NPAS1) Mouse Monoclonal Antibody [Clone ID: OTI4C10]

Human, Mouse, Rat

IHC, WB

$523
Cat # M10933
100 µl

PASD5 (NPAS1) (NM_002517) Human Over-expression Lysate

Human

$628
Cat # LS004861
100 µg

NPAS1 Overview

Facts about Neuronal PAS domain-containing protein 1.

NPAS1 3D structure. Source: alphafold

Neuronal PAS domain-containing protein 1 (NPAS1)

May control regulatory pathways relevant to schizophrenia and to psychotic illness. May play a role in late central nervous system development by regulating EPO expression in response to cellular oxygen level (By similarity).

Forms a heterodimer that binds core DNA sequence 5'-TACGTG-3' inside the hypoxia response element (HRE) resulting in transcriptional repression on its target receptor TH (By similarity). .

Gene Information

Human
Gene Name:	NPAS1
Uniprot:	Q99742
Entrez:	4861

Family

Belongs to:

No superfamily

Alternative Names

Basic-helix-loop-helix-PAS protein MOP5; BHLHE11; bHLHe11member of PAS superfamily 5; Class E basic helix-loop-helix protein 11; Member of PAS protein 5; MOP5Neuronal PAS1; neuronal PAS domain protein 1; neuronal PAS domain-containing protein 1; PASD5PAS domain-containing protein 5

Molecular Weight

Mass (kDA):
62.702 kDA

Genomic Context


Human

Location:	19q13.32
Sequence:	19; NC_000019.10 (47019837..47045775)

Subcellular Localizations

Nucleus.

Diseases

Nervousness
Schizophrenia
Neoplasms
Globus Hystericus
Cholangiocarcinoma
Skin Neoplasms
Melanoma
Malignant Neoplasm Of Breast
Malignant Paraganglionic Neoplasm
Parkinson Disease
Psychotic Disorders

Dysplasia
Melanocytic Nevus
Dysplastic Nevus
Malignant Neoplasms
Dysplastic Nevus Syndrome
Mammary Neoplasms

Pathways

Cell Differentiation
Cell Proliferation
Cell Migration
Prepulse Inhibition
Neuroendocrine Cell Differentiation
Lung Development
Neurogenesis
Nuclear Export
Localization
Startle Response
Tube Development

System Development
Neural Precursor Cell Proliferation
Nervous System Development
Central Nervous System Development
Neural Tube Development
Chromatin Remodeling

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NPAS1

References

PMID: 9012850 by Zhou Y.-D., et al. Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system.

PMID: 9079689 by Hogenesch J.B., et al. Characterization of a subset of the basic-helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway.