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Nephrocystin-1 Antibodies
AND NPHP1 ELISA kits, Nephrocystin-1 Proteins
Many biological assays use antibodies to detect Nephrocystin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Nephrocystin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Nephrocystin-1 antibodies...
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NPHP1 Infographic by Boster Bio
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NPHP1 Overview
Facts about Nephrocystin-1.
Nephrocystin-1 (NPHP1)
Involved in the organization of apical junctions in kidney cells together with NPHP4 and RPGRIP1L/NPHP8 (By similarity). Does not seem to be strictly required for ciliogenesis (By similarity).
Seems to help to recruit PTK2B/PYK2 to cell matrix adhesions, thereby initiating phosphorylation of PTK2B/PYK2 and PTK2B/PYK2-dependent signaling. May play a role in the regulation of intraflagellar transport (IFT) during cilia assembly.
Gene Information
| Human | |
|---|---|
| Gene Name: | NPHP1 |
| Uniprot: | O15259 |
| Entrez: | 4867 |
Family
| Belongs to: |
|---|
| nephrocystin-1 family |
Alternative Names
FLJ97602; JBTS4NPH1Juvenile nephronophthisis 1 protein; nephrocystin 1; nephrocystin-1; nephronophthisis 1 (juvenile); SLSN1
Molecular Weight
Mass (kDA):
83.299 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q13 |
| Sequence: | 2; NC_000002.12 (110122311..110205013, complement) |
Tissue Specificity
Widespread expression, with highest levels in pituitary gland, spinal cord, thyroid gland, testis, skeletal muscle, lymph node and trachea. Weakly expressed in heart, kidney and pancreas. Expressed in nasal epithelial cells (at protein level).
Subcellular Localizations
Cell junction. Cell junction, adherens junction. Cell projection, cilium. Cytoplasm, cytoskeleton, cilium axoneme. Cell junction, tight junction. In the retinal photoreceptor cell layer, localizes at the connecting cilium (By similarity). Colocalizes with E-cadherin and BCAR1 at or near the cell-cell adherens junctions (By similarity). Localized to respiratory cilia axoneme (PubMed:16308564, PubMed:16885411). Localized to the transition zone of respiratory cilia (PubMed:16885411). Localized to the transition zone of photoreceptor-connecting cilia and renal monocilia (By similarity). In culture
Diseases
- Nephronophthisis
- Kidney Diseases
- Cystic Kidney Diseases
- Kidney Failure, Chronic
- Kidney Failure
- Nephronophthisis, Familial Juvenile
- Familial Aplasia Of The Vermis
- Hydrocephalus, Normal Pressure
- Fibrosis
- Retinitis Pigmentosa
- Ataxia
- Nephritis, Interstitial
Interacting Proteins
- ADAM15
- AHI1
- NPHP4
- PKD1
- PTK2B
Pathways
- Localization
- Transport
- Pathogenesis
- Intraflagellar Transport
- Cell Adhesion
- Cell Cycle
- Brain Development
- Cytoskeleton Organization
- Mating
- Epithelial Cell-cell Adhesion
- Cell Migration
- Reflex
- Spermatogenesis
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NPHP1
bosterbio.com/bosterbio-gene-info-cards/NPHP1
References
PMID: 9361039 by Saunier S., et al. A novel gene that encodes a protein with a putative src homology 3 domain is a candidate gene for familial juvenile nephronophthisis.
PMID: 9326933 by Hildebrandt F., et al. A novel gene encoding an SH3 domain protein is mutated in nephronophthisis type 1.