NADPH oxidase organizer 1 (Noxo1)

Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is necessary for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3.

Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. .