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NLRP3 Antibodies
AND NLRP3 ELISA kits, NLRP3 Proteins
Many biological assays use antibodies to detect NLRP3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with NLRP3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop NLRP3 antibodies...
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NLRP3 Video by Boster Bio
All NLRP3 Products
Product
Figures
Specificity
Applications
Price
Anti-CIAS1/NALP3/NLRP3 Antibody Picoband®
18 Citations 18 Q&As
Human, Mouse, Rat
Flow Cytometry, IHC, WB
$370
Cat # PA1665
100 μg/vial
Cat # PA1665
100 μg/vial
Anti-NALP3 NLRP3 Rabbit Monoclonal Antibody
14 Citations 17 Q&As
Human
IF, IHC, ICC, WB
$370
Cat # M00034
100 μl
Cat # M00034
100 μl
Anti-NLRP3 Antibody
8 Citations
Human, Mouse, Rat
Flow Cytometry, IP, IF, IHC, ICC, WB
$405
Cat # A00034-1
100ul
Cat # A00034-1
100ul
Anti-CIAS1/NALP3/NLRP3 Antibody Picoband®
14 Citations
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00034-2
100 μg/vial
Cat # A00034-2
100 μg/vial
NLRP3 Overview
Facts about NACHT, LRR and PYD domains-containing protein 3.
NACHT, LRR and PYD domains-containing protein 3 (NLRP3)
As the sensor part of the NLRP3 inflammasome, plays an essential role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the creation of the inflammasome polymeric complex, made from NLRP3, PYCARD and CASP1 (and possibly CASP4 and CASP5).
Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1- catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu (PubMed:28847925). Activation of NLRP3 inflammasome is also required for HMGB1 secretion (PubMed:22801494).
Gene Information
| Human | |
|---|---|
| Gene Name: | NLRP3 |
| Uniprot: | Q96P20 |
| Entrez: | 114548 |
Family
| Belongs to: |
|---|
| NLRP family |
Alternative Names
AGTAVPRL; AII; AII/AVP; Angiotensin/vasopressin receptor AII/AVP-like; mouse NLRP3; NLRP3; AVP; C1orf7; Caterpiller protein 1.1; CIAS1; CLR1.1; Cold autoinflammatory syndrome 1 protein; Cold autoinflammatory syndrome 1; Cryopyrin; Familial cold autoinflammatory syndrome; FCAS; FCU; Leucine-rich repeat-, and PYD-containing protein 3; Muckle-Wells syndrome; MWS; NACHT; NACHT, LRR and PYD containing protein 3; NACHT, LRR and PYD domains-containing protein 3; NALP3; NLR family, pyrin domain containing 3; NLRP3 mouse; NLRP3 polyclonal; NLRP3 rat; NLRP3; Nucleotide-Binding Oligomerization Domain, Le
Molecular Weight
Mass (kDA):
118.173 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q44 |
| Sequence: | 1; NC_000001.11 (247416163..247448823) |
Tissue Specificity
Predominantly expressed in macrophages. Also expressed in dendritic cells, B- and T-cells (at protein level) (PubMed:11786556) (PubMed:17164409). Expressed in LPS-treated granulocytes, but not in resting cells (at protein level) (PubMed:17164409). Expression in monocytes is very weak (at protein level) (PubMed:17164409). Expressed in stratified non- keratinizing squamous epithelium, including oral, esophageal and ectocervical mucosa and in the Hassall's corpuscles in the thymus. Also, detected in the stratified epithelium covering the bladder and ureter (transitional mucosa) (at protein level) (PubMed:17164409). Expressed in chondrocytes (PubMed:12032915). Expressed at low levels in resting osteoblasts (PubMed:17907925).
Subcellular Localizations
Cytoplasm, cytosol. Inflammasome. Endoplasmic reticulum. Secreted. Nucleus. In macrophages, under resting conditions, mainly located in the cytosol, on the endoplasmic reticulum. After stimulation with inducers of the NLRP3 inflammasome, mitochondria redistribute in the vicinity of the endoplasmic reticulum in the perinuclear region, which results in colocalization of NLRP3 on the endoplasmic reticulum and PYCARD on mitochondria, allowing the activation of inflammasome assembly. After the induction of pyroptosis, inflammasome specks are released into the extracellular space where they can furt
Diseases
- Inflammation
- Cryopyrin-associated Periodic Syndromes
- Autoimmune Diseases
- Muckle-wells Syndrome
- Urticaria
- Arthritis
- Familial Mediterranean Fever
- Innate Immune Response
- Inflammatory Disorder
- Chronic Infantile Neurological, Cutaneous, And Articular Syndrome
- Familial Cold Urticaria
- Inflammatory Response
Interacting Proteins
- EIF2AK2
- MAVS
- Nek7
- PYCARD
Pathways
- Secretion
- Pathogenesis
- Immune Response
- Cell Death
- Inflammatory Response
- Innate Immune Response
- Pyroptosis
- Cytokine Production
- Phagocytosis
- Virulence
- Autophagy
- Cell Activation
- Chemotaxis
PTMs
- Cleavage
- Phosphorylation
- Ubiquitination
- Nitrosylation
Research Areas
- Alzheimers Research
- Apoptosis
- Cancer
- Cytokine Research
- Immunology
- Inflammation
- Neurodegeneration
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/NLRP3
bosterbio.com/bosterbio-gene-info-cards/NLRP3
References
PMID: 11687797 by Hoffman H.M., et al. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome.
PMID: 12355493 by Aganna E., et al. Association of mutations in the NALP3/CIAS1/PYPAF1 gene with a broad phenotype including recurrent fever, cold sensitivity, sensorineural deafness, and AA amyloidosis.
25 Publications of Boster NLRP3 Antibodies & ELISA Kits
- PubMed ID: 10.1161/ATVBAHA.120.315525, Circular RNA Calm4 Regulates Hypoxia-Induced Pulmonary Arterial Smooth Muscle Ce...
- PubMed ID: 10.1155/2021/6687555, TLR4-NLRP3-GSDMD-Mediated Pyroptosis Plays an Important Role in Aggravated Liver...
- PubMed ID: 10.1016/j.freeradbiomed.2017.05.003, Quercetin suppresses NLRP3 inflammasome activation in epithelial cells triggered...
- PubMed ID: 10.1016/j.cbi.2021.109572, Pelargonic acid vanillylamide and rosuvastatin protect against oxidized low-dens...
- PubMed ID: 10.1016/j.bbrc.2021.03.009, Inhibition of endotoxin-induced acute lung injury in rats by bone marrow–deriv...
- PubMed ID: 10.1002/tox.22943, Mangiferin inhibits lipopolysaccharide‐induced epithelial‐mesenchymal transi...
- PubMed ID: 10.1002/jbt.22978, The combination of dapagliflozin and statins ameliorates renal injury through at...
- PubMed ID: 31156617, Wei Z,Wang J,Wang Y,Wang C,Liu X,Han Z,Fu Y,Yang Z.Effects of Neutrophil Extrace...
- PubMed ID: 34217687, Sivasinprasasn S,Wikan N,Tocharus J,Chaichompoo W,Suksamrarn A,Tocharus C.Pelarg...
- PubMed ID: -, Huiqing Zhang,Yuna Du,Yujie Guo,Zeyu Wang,Hua Li,Zhe Lv,Lifeng Zeng,Yiguo Chen,Z...
- PubMed ID: 33713981, Lei L,Guo Y,Lin J,Lin X,He S,Qin Z,Lin Q. Inhibition of endotoxin-induced acute ...
- PubMed ID: 32908485, Du X,Xu Y,Chen S,Fang M.Inhibited CSF1R Alleviates Ischemia Injury via Inhibitio...
- PubMed ID: 33550074, Hou J,Lei Z,Cui L,Hou Y,Yang L,An R,Wang Q,Li S,Zhang H,Zhang L.Polystyrene micr...
- PubMed ID: 33422654, Xia S,Yang P,Li F,Yu Q,Kuang W,Zhu Y,Lu J,Wu H,Li L,Huang H.Chaihu-Longgu-Muli D...
- PubMed ID: 33434657, Huang Y,Wang S,Huang F,Zhang Q,Qin B,Liao L,Wang M,Wan H,Yan W,Chen D,Liu F,Jian...
- PubMed ID: -, Zuowei Pei,Ying Guo,Huolan Zhu et al.Thymoquinone protects against hyperlipemia-...
- PubMed ID: -, Qianrui Zhang,Sheng Zhao,Wenxia Zheng,Haitan Fu,Tao Wu & Fei Hu (2020) Plumbagin...
- PubMed ID: 32229117, Hu M,Wu X,Luo M,Wei H,Xu D,Xu F. Lactobacillus rhamnosus FLRH93 protects against...
- PubMed ID: 33068158, Yang R,Jia Q,Mehmood S,Ma S,Liu X.Genistein ameliorates inflammation and insulin...
- PubMed ID: 32789796, Liu R,Wu S,Guo C,Hu Z,Peng J,Guo K,Zhang X,Li J.Ibuprofen Exerts Antiepileptic a...
- PubMed ID: 33259938, Jiang S, Zhang H, Li X, Yi B, Huang L, Hu Z, Li A, Du J, Li Y, Zhang W. Vitamin ...
*Showing only the more recent 20. More publications can be found for each product on its corresponding product page